CSBR Living Stocks: Continued Support of the Duke Lemur Center for the Study of Primate Biology and History

CSBR 活畜：杜克狐猴灵长类生物学和历史研究中心的持续支持

• 批准号: 1561691
• 负责人: Anne Yoder
• 金额: $ 50万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1561691&HistoricalAwards=false
• 关键词: CSBR; Living; Stocks; Continued; Support

The Duke Lemur Center (DLC) is a unique institution dedicated to the study and care of the world's most endangered and biologically diverse primates: The lemurs of Madagascar. The DLC was founded on the principle that the study of lemurs and related primates can inform larger questions in biology such as the genetic and biological underpinnings of the human condition. Investigators and students from around the world come to Duke to study the living and fossil collections of the DLC. The DLC serves as a unique center for scientific inquiry, a hub for student activity, a nexus of knowledge, and a global partner for understanding and mitigating the Earth's escalating environmental challenges. Founded on the unifying themes of scientific inquiry, scholarship, information, and global engagement, the DLC will capitalize on recent revolutions in genomics, informatics and nanotechnology to make possible much more detailed investigation of its endangered primates and the application of these approaches for enhancing public knowledge of the scientific process. The DLC serves multiple educational communities, including the general public, K-12, undergraduate, graduate, and postgraduate students. A multitude of opportunities exist for engagement at the undergraduate and graduate student levels. In the past five years alone, more than 400 students from 98 institutions have engaged in research and/or training activities. Lemurs are endemic to the biodiversity hotspot of Madagascar, and due to their critically-endangered status, it would be impossible to recreate the taxonomic diversity of the DLC colony that presently contains 19 species. Over the past five-year period, 276 research projects led by 208 investigators from 100 institutions representing eight countries (primarily the U.S.) have been conducted at the DLC. These projects span a broad array of biological disciplines including, but not limited to, aging, behavioral ecology, biomechanics, cognition, epigenetics, life-history strategy, metabolomics, metagenomics, molecular evolution, neurophysiology, phylogeography, phylogenomics, population genetics, reproductive biology, sensory communication, speciation, and virology. During this three year project, the DLC will continue to make lemurs readily available to investigators, along with extensive collections of biological samples, decades of medical records, fossil representatives of extinct taxa, and rich life-history records. The DLC will also release a new version of the mouse lemur genome assembly, which will further enhance the research potential of the mouse lemur colony specifically, and the entire DLC colony by phylogenetic extension. In addition, the DLC will collaborate with Duke University's Center for In Vivo Microscopy, continue in vivo and ex vivo studies to produce an online multidimensional neural atlas of the dwarf and mouse lemurs. The DLC is also wholeheartedly committed to conservation activities via both ex situ captive management and in-country programs. The DLC's conservation Initiative in Madagascar has already served as a "landing pad" for numerous student and faculty researchers engaged in projects ranging from disease transmission, to behavioral ecology, to ecophysiology, to climate change. On-line access to colony inventories, demographics, metadata, research opportunities, and more is available through two web-based portals. Details on all facets of the DLC mission and activities can be found online (lemur.duke.edu).

杜克狐猴中心(DLC)是一个独特的机构，致力于研究和照顾世界上最濒危和生物多样性最大的灵长类动物：马达加斯加狐猴。DLC建立在这样一个原则上，即对狐猴和相关灵长类动物的研究可以为生物学中更大的问题提供信息，例如人类状况的遗传和生物学基础。来自世界各地的研究人员和学生来到杜克大学研究DLC的活体和化石收藏。DLC是一个独特的科学研究中心，是学生活动的中心，是知识的纽带，是了解和缓解地球不断升级的环境挑战的全球合作伙伴。DLC建立在科学研究、学术、信息和全球参与的统一主题上，将利用基因组学、信息学和纳米技术的最新革命，使对其濒危灵长类动物进行更详细的调查成为可能，并应用这些方法来增强公众对科学过程的了解。DLC服务于多个教育社区，包括普通公众、K-12、本科生、研究生和研究生。在本科生和研究生阶段有很多参与的机会。仅在过去五年中，就有来自98个机构的400多名学生从事研究和/或培训活动。狐猴是马达加斯加生物多样性热点地区特有的物种，由于它们处于极度濒危的状态，不可能重现目前包含19个物种的DLC群体的分类多样性。在过去的五年里，来自8个国家(主要是美国)的100个机构的208名研究人员领导了276个研究项目。都是在DLC进行的。这些项目涵盖广泛的生物学学科，包括但不限于衰老、行为生态学、生物力学、认知学、表观遗传学、生活史战略、代谢组学、元基因组学、分子进化、神经生理学、系统地理学、系统基因组学、种群遗传学、生殖生物学、感觉通讯、物种形成和病毒学。在这个为期三年的项目中，DLC将继续向研究人员提供狐猴，以及大量的生物样本、数十年的医疗记录、已灭绝分类群的化石代表和丰富的生活史记录。DLC还将发布新版本的小鼠狐猴基因组组件，这将进一步增强小鼠狐猴群体的研究潜力，特别是通过系统发育扩展来提升整个DLC群体的研究潜力。此外，DLC将与杜克大学体内显微镜中心合作，继续进行体内和体外研究，以制作在线多维神经图谱，研究侏儒狐猴和小鼠狐猴。DLC还通过迁地圈养管理和国内计划全心全意地致力于保护活动。DLC在马达加斯加的保护倡议已经成为从事从疾病传播到行为生态学、生态生理学到气候变化等项目的众多学生和教师研究人员的“着陆台”。通过两个基于网络的门户网站，可以在线访问殖民地清单、人口统计数据、元数据、研究机会等。刚果民主共和国任务和活动的所有方面的细节都可以在网上找到(lemur.duke.edu)。