Decode Neuro-Mechanobiology:mechanosensitive ion channels in proprioception

解码神经机械生物学：本体感觉中的机械敏感离子通道

• 批准号: DE230101128
• 负责人: Dr Shaopeng Chi
• 金额: $ 31.3万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-14 至 2026-07-13
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101128
• 关键词: Decode; Neuro; Mechanobiology; mechanosensitive; ion

Human bodies are densely covered with numerous mechanosensory neurons that provide us with the sense of touch and pain. However, the molecular force sensors remain poorly identified. This project aims at defining the fundamental roles of mechanosensitive ion channels to sense and respond to various mechanical stimuli, and how their responses may encode mechanical cues.The ultimate goal is to provide a fundamentally new understanding of proprioception and motion sensing. The new multimodality approach generated in this project is expected to evolve as a national facility for neuro-mechanobiology, and future research may lead to the inspiration of novel bionic sensor design and brain-computer interface for future neuroengineering industry.

人体上密布着无数的机械感觉神经元，它们为我们提供触觉和痛觉。然而，分子力传感器仍然很难识别。本项目旨在明确机械敏感离子通道在感知和响应各种机械刺激中的基本作用，以及它们的响应如何编码机械提示。最终目标是提供对本体感受和运动感知的全新理解。该项目中产生的新的多模态方法有望发展成为神经机械生物学的国家设施，未来的研究可能会为未来的神经工程行业带来新型仿生传感器设计和脑机接口的灵感。