Elaboration of a Stereoselective Protocol for the Synthesis of Carbon Glycosides

碳苷合成立体选择性方案的阐述

• 批准号: 9312020
• 负责人: Ronald Caple
• 金额: $ 20.4万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9312020&HistoricalAwards=false
• 关键词: Elaboration; Stereoselective; Protocol; Synthesis; Carbon

9312020 Caple The focus of this research is the elaboration of a stereoselective protocol for carbon glycoside synthesis. Variations in the nature of carbon nucleophiles capable of undergoing reaction with ESI intermediates derived from the protected glucal, attempts to control stereochemistry, possible utilization of a series of glycals and the synthesis of targets related to bioactive target molecules will be carried out. %%% With this Research in Undergraduate Institutions renewal award, the Synthetic Organic Program is supporting the research of Dr. Ronald Caple of the Department of Chemistry at the University of Minnesota, Duluth, which will done in close collaboration with Dr. William A. Smit of the Zelinski Institute of Organic Chemistry, Rusian Academy of Science, Moscow. The focus of the work is the development of methodology for the controlled preparation of carbon glycosides. The involvement of undergraduates is a vital component of the project.

本研究的重点是碳糖苷合成的立体选择方案的阐述。本研究将研究能够与受保护的葡聚糖衍生的ESI中间体发生反应的碳亲核试剂的性质变化、控制立体化学的尝试、一系列糖基的可能利用以及与生物活性靶分子相关的靶标的合成。有了这个本科院校研究更新奖，合成有机项目将支持德卢斯明尼苏达大学化学系Ronald capple博士的研究，该研究将与莫斯科俄罗斯科学院Zelinski有机化学研究所的William A. Smit博士密切合作。研究的重点是碳苷的可控制备方法的发展。大学生的参与是这个项目的重要组成部分。