一种制备生物活性有机磷酸酯膦酸酯类似物的新合成方法-猫眼课题宝

一种制备生物活性有机磷酸酯膦酸酯类似物的新合成方法

批准号：

9312231

负责人：

Cynthia McClure

金额：

$20.52万

依托单位：

University of Delaware

依托单位国家：

美国

项目类别：

Continuing Grant

财政年份：

1993

资助国家：

美国

项目状态：

已结题

起止时间：

1993-08-01 至 1996-04-30

来源：

https://www.nsf.gov/awardsearch/showAward?AWD_ID=9312231&HistoricalAwards=false

关键词：

New Synthetic Method Preparation Phosphonate

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9312231 McClure The focus of this research is the development of pentavalent organophospholene chemistry as a new synthetic method for the production of phosphonate-containing compounds. The oxophospholenes will be condensed with a variety of electrophiles to give highly substituted phosphonates. The phosphonates, in turn, will provide intermediates for the production of inositol phosphates, sphingomyelins, carbohydrates and C-nucleoside analogs. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Cynthia K. McClure of the Department of Chemistry at the University of Delaware. Professor McClure will focus her work on the synthesis of simple phosphonate analogs of biologically active phosphates. The target compounds are of potential interest as antimetabolites and enzyme active- site probes. ***

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