A New Synthetic Method For the Preparation of Phosphonate Analogs of Bio-active Organophosphates

一种制备生物活性有机磷酸酯膦酸酯类似物的新合成方法

• 批准号: 9312231
• 负责人: Cynthia McClure
• 金额: $ 20.52万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1996-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9312231&HistoricalAwards=false
• 关键词: New; Synthetic; Method; Preparation; Phosphonate

9312231 McClure The focus of this research is the development of pentavalent organophospholene chemistry as a new synthetic method for the production of phosphonate-containing compounds. The oxophospholenes will be condensed with a variety of electrophiles to give highly substituted phosphonates. The phosphonates, in turn, will provide intermediates for the production of inositol phosphates, sphingomyelins, carbohydrates and C-nucleoside analogs. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Cynthia K. McClure of the Department of Chemistry at the University of Delaware. Professor McClure will focus her work on the synthesis of simple phosphonate analogs of biologically active phosphates. The target compounds are of potential interest as antimetabolites and enzyme active- site probes. ***

9312231麦克卢尔本研究的重点是五价有机芴化学的发展，作为一种新的合成方法，用于生产含膦酸酯的化合物。 氧代磷烯将与各种亲电试剂缩合，得到高度取代的膦酸酯。 膦酸盐又将提供用于生产肌醇磷酸、鞘磷脂、碳水化合物和C-核苷类似物的中间体。 有了这个奖项，合成有机计划正在支持博士的研究。 特拉华州大学化学系的麦克卢尔说。 麦克卢尔教授将把她的工作重点放在生物活性磷酸盐的简单膦酸盐类似物的合成上。 目标化合物作为抗代谢药物和酶活性位点探针具有潜在的应用价值. ***