Investigations of the Use of Pentacovalent Organophosphorus Compounds in the Production of Phosphonates

五共价有机磷化合物在膦酸盐生产中的应用研究

• 批准号: 9709558
• 负责人: Cynthia McClure
• 金额: $ 34.45万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9709558&HistoricalAwards=false
• 关键词: Investigations; Use; Pentacovalent; Organophosphorus; Compounds

The focus of this research is to develop synthetic methodology using the condensations of pentacovalent oxaphospholenes (P(V)'s) with various electrophiles for the production of highly substituted phosphonates. The methodology will be be applied to the synthesis of phosphonate analogs of biologically active organophosphates. The reactivities of P(V)'s with differing ligand on phosphorus and the mechanism(s) of the condensations between P(V)'s and electrophiles will also be explored. With this renewal award, the Synthetic Organic Program and the Office of Mutlidisciplinary Activities are supporting the research of Dr. Cynthia K. McClure of the Department of Chemistry at Montana State University. Professor McClure will focus her work on developing methods for the preparation of phosphonate containing compounds of biological interest as antimetabolites and enzyme active probes. Compounds of this type could have medicinal value as antivirals, antibiotics, antiacidosis agents and could exhibit herbicidal and insecticidal activity.

本研究的重点是开发利用五价氧磷烯（P(V) s）与各种亲电试剂缩合生产高取代磷酸盐的合成方法。该方法将被应用于合成具有生物活性的有机磷酸盐的膦酸盐类似物。本文还将探讨P(V)与不同配体在磷上的反应活性以及P(V)与亲电试剂之间缩合反应的机理。有了这个更新奖，合成有机项目和多学科活动办公室支持蒙大拿州立大学化学系的辛西娅·k·麦克卢尔博士的研究。麦克卢尔教授将专注于开发制备含有抗代谢产物和酶活性探针等生物学意义的膦酸盐化合物的方法。这类化合物具有抗病毒、抗生素、抗酸中毒等药用价值，并具有除草、杀虫活性。