Development of New Methods for Alkaloid Synthesis via the Oxa-di-pi-Methane Rearrangement and Radical Chemistry

妇女研究规划补助金的研究机会 属于有机化学的一般领域。 Cynthia K博士 密歇根大学化学系的麦克卢尔说， 特拉华州将探索两种不同的合成方法 生物碱的氮杂环亚结构。 一 方法是光化学氧杂二π甲烷重排 酰胺和其他含氮化合物， 吡咯里西啶和吲哚里西啶生物碱骨架。 第二 方法包括将自由基加成到 亚胺化酯以形成新的碳-氮键 非离子条件。 如果成功的话，这些方法可以 用于生物活性生物碱的全合成 以及它们的类似物，并提出了一项持续研究的建议， 地区可以发展。

This Research Opportunities for Women Research Planning Grant is in the general area of organic chemistry. Dr. Cynthia K. McClure of the Chemistry Department of the University of Delaware will explore two different methods for the synthesis of the nitrogen heterocyclic substructures of alkaloids. One method is the photochemical oxa-di-pi-methane rearrangement of amides and other nitrogen-containing compounds to produce pyrrolizidine and indolizidine alkaloid skeletons. The second method involves the addition of radicals to the nitrogen of imidate esters to form a new carbon-nitrogen bond under non-ionic conditions. If successful, these methods could be used in the total synthesis of biologically active alkaloids and their analogs and a proposal for sustained study in that area could be developed.