POWRE: Synthesis of Alkaloids via a Photochemical Methodology

POWRE：通过光化学方法合成生物碱

• 批准号: 9753270
• 负责人: Cynthia McClure
• 金额: $ 6.85万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9753270&HistoricalAwards=false
• 关键词: POWRE; Synthesis; Alkaloids; via; Photochemical

This award from the Professional Opportunities for Women in Research and Education (POWRE) program for the research and educational activities of Professor Cynthia McClure of Montana State University is supported by funds provided by the National Institutes of Health through interagency transfer to NSF. The research enabled by the POWRE award aims at a new synthetic methodology for production of nitrogen heterocycles of biomedical significance. Professor McClure, an established researcher in organophosphorus chemistry, will undertake exploratory study of the oxa-di-pi-methane photochemical rearrangement of a series of aza-bicyclic systems, with a view to using the reaction as a method for constructing the ring system that is present in a number of pyrrolizidine and indolizidine alkaloid structures. Many of these alkaloids exhibit potent antibiotic and anti-tumor properties. The opportunity afforded through the POWRE program will enhance Professor McClure's research and leadership potential and her educational mentoring of undergraduate and graduate students.

该奖项由研究和妇女专业机会组织颁发， 教育（POWRE）计划的研究和教育活动， 蒙大拿州立大学的辛西娅麦克卢尔教授得到了 美国国立卫生研究院通过跨机构提供的资金 转到NSF。 POWRE奖所支持的研究旨在实现一种新的 用于制备氮杂环化合物合成方法 生物医学意义 麦克卢尔教授是一位知名的 有机磷化学，将进行探索性研究， 一系列氮杂双环的氧杂二π-甲烷光化学重排 系统，以期利用反应作为一种方法， 存在于许多吡咯里西啶中的环系统， 吲哚里西啶生物碱结构。这些生物碱中的许多表现出强有力的 抗生素和抗肿瘤特性。 通过POWRE计划提供的机会将提高教授 麦克卢尔的研究和领导潜力以及她的教育指导 本科生和研究生。