U.S.-Netherlands Cooperative Research on the Role of Phyto- chrome in the Regulation of Mitosis in Pea Epicotyls

9313805 Roux该奖项支持德克萨斯大学奥斯汀分校的Stanley J. Roux教授和博士后Gregory Clark博士与Richard E.荷兰瓦赫宁根农业大学植物生理学系的Kendrick博士说。 他们的研究目的是更好地了解豌豆细胞中光诱导核数量增加的原因，这是Roux教授和Clark博士最近发现的一种现象。 与肯德里克教授和他所在机构的其他人一起，他们正在采取多学科方法来研究色素光敏色素在刺激有丝分裂中的假定作用的生化基础。 特别是，他们正在探索这种作用是否通过GTP结合蛋白介导。他们的研究依赖于两个小组的互补专业知识。 Kendrick博士是光敏色素研究的生理学和光生物学方面的世界领导者，也是G蛋白介导光敏色素反应研究的先驱。 他所在机构的其他人将贡献植物发育的细胞学和形态学方面的专业知识。 Roux博士在光敏色素的生物化学方面进行了广泛的研究，并且是光敏色素调节酶的专家。 这项研究测试了光敏色素是否可以调节有丝分裂以及这种调节是否需要GTP结合蛋白的介导。 验证这种影响将有助于解释的戏剧性影响光敏色素豌豆胚芽的发展，并将代表一个非常重要的除了令人印象深刻的列表中的事件控制光敏色素在光形态建成。 验证GTP结合蛋白作为介体的作用将是一个同样重要的发现，不仅对植物科学，而且对一般的细胞生物学，因为对细胞核中GTP结合蛋白的调节几乎一无所知。 ***

9313805 Roux This award supports Professor Stanley J. Roux of the University of Texas at Austin and Dr. Gregory Clark, a postdoctoral associate, to collaborate in developmental botany research with Professor Richard E. Kendrick of the Department of Plant Physiology, Wageningen Agricultural University, The Netherlands. The objective of their research is to gain a better understanding of the cause of the light-induced increase in the nuclear number among pea cells, a phenomenon which was recently discovered by Professor Roux and Dr. Clark. Together with Professor Kendrick and others at his institution, they are taking a multidisciplinary approach to studying the biochemical basis for the postulated role of the pigment phytochrome in the stimulation of mitosis. In particular, they are exploring whether this role is mediated through GTP-binding proteins. Their research depends on the complementary expertise of the two groups. Dr. Kendrick is a world leader in the physiological and photobiological aspects of phytochrome research and a pioneer on studies of G-protein mediation of phytochrome responses. Others in his institution will contribute expertise in the cytological and morphological aspects of plant development. Dr. Roux has worked extensively on biochemical aspects of phytochrome, and is an expert on enzymes regulated by phytochrome. This research tests the important question of whether phytochrome can regulate mitosis and whether this regulation requires the mediation of GTP-binding proteins. Verification of this influence will help explain the dramatic effects of phytochrome on pea plumule development and will represent a critically important addition to the impressive list of events controlled by phytochrome during photomorphogenesis. Verification of a role for GTP-binding proteins as mediators would be an equally important finding, not only for plant sciences but for cell biology in general, for almost nothing is known about the regulation of GTP -binding proteins in nuclei. ***