Gordon Research Conference on "Oxygen Radicals in Biology", to be held February 6-11, 1994, Ventura, California

戈登研究会议“生物学中的氧自由基”，将于 1994 年 2 月 6 日至 11 日在加利福尼亚州文图拉举行

• 批准号: 9315902
• 负责人: Donald Reed
• 金额: $ 0.4万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9315902&HistoricalAwards=false
• 关键词: Gordon; Research; Conference; Oxygen; Radicals

Reed 9315902 The Gordon Research Conference on "Oxygen Radicals in Biology" is designed to provide chemists, biophysicist, biochemists, cell biologists, clinicians, radiologists and other biomedical scientists with "cutting edge" science on oxygen radicals in chemical and biological systems. This research conference is held every two years; the next meeting will be held February 6-11, 1994, at the Doubletree Hotel, Ventura, California. Seven conferences have been held since 1981 and they have proven to be extremely productive based on the large number of applicants and the post-meeting evaluations. Funds are requested to partially support travel, subsistence and registration costs for speakers and session chairs from the United States and one individual from Canada. All attendees at the past two conferences were invited to submit suggestions for the prograrn to be presented in 1994. Nearly one half replied, and their suggestions were used along with those from some principal advisors to select and invite the speakers listed in the 1994 program. All speakers have accepted the invitation to describe their frontier research on oxygen radicals in biology. Topics to be covered include: (i) superoxide radical, superoxide dismutase, familial amyotrophic lateral sclerosis (FALS), SOD mimics; (ii) nitric oxide and peroxynitrite chemistry and pathology, nitric oxide synthesis, nitric oxide progenitors and toxicology, nitric oxide and cell signaling, (iii) oxidants and gene regulation, antioxidants and gene regulation, free radical base damage and DNA replication, reclox regulation of gene expression and DNA repair, (iv) in vivo sources of iron and generation of oxidative stress, iron regulatory element and ferritin gene expression, (v) in vivo radical detection methods, (vi) antioxidants and peroxidation of lipoproteins, radical damage and disease. In addition there will be a plenary evening lecture on the biological consequences of oxidative stress. Two separate poster session of two days each are scheduled for an anticipated 75-80 posters. Total attendance is limited to 135 by Gordon Conference rules. The Gordon Research Conference provides an excellent and needed forum for the diversity of both participants and research areas. The main strength of this Gordon Research Conference is the opportunities offered for scientists in different disciplines to interact in an extended and uninterrupted fashion. Cross fertilization of cognate fields occurs and attendees frequently establish new collaborative research initiatives. The Gordon Research Conference on Oxygen Radicals in Biology plays a crucial role in establishing frontier research in an increasingly important and clinically relevant field. %%% The Gordon Research Conference on "Oxygen Radicals in Biology" is designed to provide chemists, biophysicist, biochemists, cell biologists, clinicians, radiologists and other biomedical scientists with "cutting edge" science on oxygen radicals in chemical and biological systems. This research conference is held every two years; the next meeting will be held February 6-11, 1994, at the Doubletree Hotel, Ventura, California. Frontier research on oxygen radicals in biology will be presented and discussed in detail in an informal setting. Topics to be covered include: (i) key aspects of diseases that appear to be related to failure to protect against the toxic effects of oxygen. Thus the Conference will learn the latest information of the active forms oxygen, the superoxide radical, and the enzyme, superoxide dismutase, recently found to be associated with Lou Gehrigs disease. This disease of the motor functions of the central nervous system is also known as familial amyotrophic lateral sclerosis (FALS). New agents and possible drugs for the disease, superoxide dismutase (SOD) mimics will be described including how they may in the future substitute for the damaged SOD that appears to have undergone mutation in some of the patients with FALS. A most exciting aspect o f the Conference will be the sessions on the cell signaling system based on a toxic gas, nitric oxide, (NO). This compound is also important in the killing of foreign bacteria by its reaction with active oxygen, superoxide radical, to form an even more toxic compound. peroxynitrite. The chemistry and pathology of this compound should provide very important information about various systems in the body that are important for our protection by the white cells or leukocytes of the blood against infections. We now know that oxygen-based stress can cause gene regulation, thus the need for antioxidants such as vitamin E to protect against gene damage can be related to free radical base damage and repair. In vivo sources of iron generate oxidative stress by activation of oxygen. Thus, iron regulatory element and ferritin (an iron carrying protein) gene expression are essential for the control of iron in the body. These will be discussed in some detail. In vivo radical detection methods, antioxidants and peroxidation of lipoproteins, radical damage and related diseases are also topics for the Conference. In addition there will be a plenary evening lecture on the biological consequences of oxidative stress and relationships to human diseases and aging. Two separate poster session of two days each are scheduled for an anticipated 75-80 posters. Total attendance is limited to 135 by Gordon Conference rules. The Gordon Research Conference provides an excellent and needed forum for the diversity of both participants and research areas. The main strength of this Gordon Research Conference is the opportunities offered for scientists in different disciplines to interact in an extended and uninterrupted fashion. Cross fertilization of cognate fields occurs and attendees frequently establish new collaborative research initiatives. The Gordon Research Conference on Oxygen Radicals in Biology plays a crucial role in establishing frontier research in an increasingly important and clinically releva nt field. ***

戈登“生物学中的氧自由基”研究会议旨在为化学家、生物物理学家、生物化学家、细胞生物学家、临床医生、放射科医生和其他生物医学科学家提供化学和生物系统中氧自由基的“前沿”科学。该研究会议每两年举行一次；下一次会议将于1994年2月6日至11日在加州文图拉的双树旅馆举行。自1981年以来已经举行了七次会议，根据大量的申请者和会后评价，这些会议证明是极具成效的。所请经费部分用于支付来自美国的发言者和会议主席以及来自加拿大的一名个人的旅费、生活津贴和登记费。过去两次会议的所有与会者都被邀请为1994年提出的方案提出建议。将近一半的人回答了，他们的建议和一些主要顾问的建议被用来选择和邀请1994年计划中列出的演讲者。所有的演讲者都接受了邀请，介绍了他们在生物学中氧自由基的前沿研究。涵盖的主题包括：(i)超氧化物自由基，超氧化物歧化酶，家族性肌萎缩侧索硬化症（FALS）， SOD模拟物；（ii）一氧化氮和过氧亚硝酸盐化学和病理学、一氧化氮合成、一氧化氮祖细胞和毒理学、一氧化氮和细胞信号传导；（iii）氧化剂和基因调控、抗氧化剂和基因调控、自由基碱基损伤和DNA复制、基因表达和DNA修复的再锁调控；（iv）体内铁的来源和氧化应激的产生、铁调节元件和铁蛋白基因表达；(v)体内自由基检测方法；（六）抗氧化剂和脂蛋白过氧化、自由基损伤和疾病。此外，晚上将有一个关于氧化应激的生物学后果的全体会议讲座。预计将有75-80张海报展出，每次为期两天。根据戈登会议的规定，总出席人数不得超过135人。戈登研究会议为参与者和研究领域的多样性提供了一个极好的和必要的论坛。这次戈登研究会议的主要优势是为不同学科的科学家提供了以扩展和不间断的方式进行互动的机会。同源领域发生交叉施肥，与会者经常建立新的合作研究计划。生物学中氧自由基戈登研究会议在建立一个日益重要的临床相关领域的前沿研究方面发挥着至关重要的作用。戈登“生物学中的氧自由基”研究会议旨在为化学家、生物物理学家、生物化学家、细胞生物学家、临床医生、放射科医生和其他生物医学科学家提供化学和生物系统中氧自由基的“前沿”科学。该研究会议每两年举行一次；下一次会议将于1994年2月6日至11日在加州文图拉的双树旅馆举行。在生物学中氧自由基的前沿研究将在非正式环境中详细介绍和讨论。将要讨论的主题包括：(i)似乎与未能防止氧气毒性作用有关的疾病的主要方面。因此，会议将了解最近发现与卢伽rig病有关的活性形式氧、超氧化物自由基和酶、超氧化物歧化酶的最新信息。这种中枢神经系统运动功能疾病也被称为家族性肌萎缩性侧索硬化症（FALS）。超氧化物歧化酶（SOD）模拟物将描述这种疾病的新药物和可能的药物，包括它们如何在未来替代在一些FALS患者中似乎发生突变的受损SOD。会议最令人兴奋的一个方面将是关于基于有毒气体一氧化氮（NO）的细胞信号系统的会议。这种化合物通过与活性氧、超氧自由基反应形成毒性更强的化合物，在杀死外来细菌方面也很重要。过氧亚硝基。这种化合物的化学和病理学应该为我们提供关于身体各个系统的重要信息，这些系统对我们保护白细胞或血液中的白细胞免受感染很重要。我们现在知道，氧基应激可以引起基因调节，因此需要抗氧化剂，如维生素E来保护基因免受损伤，这可能与自由基基损伤和修复有关。体内铁源通过激活氧产生氧化应激。因此，铁调控元件和铁蛋白（一种载铁蛋白）基因的表达对体内铁的控制至关重要。我们将详细讨论这些问题。体内自由基检测方法、抗氧化剂和过氧化脂蛋白、自由基损伤和相关疾病也是会议的主题。此外，晚上将有一个关于氧化应激的生物学后果及其与人类疾病和衰老的关系的全体会议讲座。预计将有75-80张海报展出，每次为期两天。根据戈登会议的规定，总出席人数不得超过135人。戈登研究会议为参与者和研究领域的多样性提供了一个极好的和必要的论坛。这次戈登研究会议的主要优势是为不同学科的科学家提供了以扩展和不间断的方式进行互动的机会。同源领域发生交叉施肥，与会者经常建立新的合作研究计划。生物学中氧自由基戈登研究会议在一个日益重要和临床相关的领域建立前沿研究方面发挥着至关重要的作用。* * *