Molecular Processes in Non-Newtonian Fluids

9315906 Rotello该奖项是Rotello博士的博士后研究奖学金化学奖的启动补助金增量。研究的重点将是非牛顿流体中的分子过程。解决方案的组织将被用来模拟有序的，但由蛋白质和核酸结构的动态环境。在这些溶液中形成的动态口袋将提供酶催化中存在的许多特征，例如反应物的局部浓度和构象“压力”。这些效应的大小可以通过NMR监测，并通过修改物理条件如旋转速率和样品管尺寸来改变。分子识别和催化作用也将在非牛顿溶液中进行研究。 非牛顿流体在自然界中广泛存在，包括血液、球状蛋白质内部和原生质。这些典型的聚合物水溶液根据所施加的应力改变其粘度。这项研究将解决非牛顿条件下生物和合成聚合物的基本性质。 ***

9315906 Rotello This award is the starter grant increment of Dr. Rotello's Postdoctoral Research Fellowship in Chemistry award. The focus of the research will be on molecular processes in non-Newtonian fluids. Solution organization will be used to model the ordered, yet dynamical environment created by protein and nucleic acid structures. The dynamic pockets formed in these solutions will provide many of the features present in enzymatic catalysis such as local concentration of reactants and conformational "pressure". The magnitude of these effects can be monitored by NMR and varied by modifying physical conditions such as spin rate and sample tube size. Molecular recognition and catalysis will also be studied in non-Newtonian solutions. %%% Non-Newtonian fluids are widespread in nature including blood, the interior of globular proteins and protoplasm. These typically aqueous polymer solutions vary their viscosity as a function of the applied stress. This research will address the fundamental nature of biological and synthetic polymers under non-Newtonian conditions. ***