Recognition-Controlled Polymer Self-Assembly

识别控制的聚合物自组装

• 批准号: 0518487
• 负责人: Vincent Rotello
• 金额: $ 36.5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0518487&HistoricalAwards=false
• 关键词: Recognition; Controlled; Polymer; Self; Assembly

The Organic and Macromolecular Chemistry Program supports Professor Vincent M. Rotello at the University Massachusetts- Amherst whose work on the recognition-mediated assembly of macromolecular systems will provide unique capabilities for the bottom-up assembly of nano- and microstructures. One central theme of the current research program is the assembly of randomly substituted complementary systems into organized ensembles. This mode of self-assembly differs dramatically from the programmed interactions observed in DNA and protein structure. It likewise differs from simpler self-assembled systems both in terms of specificity and in the ability to balance specific favorable interactions with phase separation behavior. This level of control provides a new (but little understood) route to polymer self-assembly. In preliminary research funded earlier, Professor Rotello has shown that random systems featuring complementary functionality can produce systems featuring higher-order structures. In these studies, the unprecedented self-assembly of random copolymers into giant vesicles was demonstrated. In future studies, the structure and properties of these Recognition-Induced Polymersomes (RIPs) will be probed. Professor Rotello will also extend self-assembly studies to block copolymers, and explore the synthesis and properties of recognition element-functionalized alternating copolymers that feature regular intergroup spacing.The Organic and Macromolecular Chemistry Program supports Professor Vincent M. Rotello whose research will provide a roadmap for the creation of self-assembled polymer microstructures. This insight will enhance the ability to create such diverse pragmatic systems as delivery devices and micro reactors. Moreover, the program is highly multidisciplinary, featuring tools and techniques from the fields of chemistry, materials science and physics. The graduate and undergraduate students working on this research will gain an integrated understanding of these diverse methodologies, providing them with powerful tools for their future careers.

有机和高分子化学计划支持教授文森特M。Rotello博士在马萨诸塞州-阿默斯特大学的研究工作将为自下而上组装纳米和微观结构提供独特的能力。当前研究计划的一个中心主题是将随机替换的互补系统组装成有组织的合奏。这种自组装模式与DNA和蛋白质结构中观察到的程序化相互作用有很大不同。它同样不同于更简单的自组装系统，在特异性和平衡特定有利相互作用与相分离行为的能力方面。这种控制水平为聚合物自组装提供了一条新的（但鲜为人知的）途径。在早期资助的初步研究中，Rotello教授已经证明，具有互补功能的随机系统可以产生具有高阶结构的系统。在这些研究中，展示了无规共聚物前所未有的自组装成巨大囊泡。在未来的研究中，这些聚合物的结构和性能将被探讨。Rotello教授还将自组装研究扩展到嵌段共聚物，并探索具有规则基团间间距的识别元素官能化交替共聚物的合成和性质。他的研究将为自组装聚合物微结构的创建提供路线图。这种洞察力将提高创造诸如输送装置和微反应器等多样化实用系统的能力。此外，该计划是高度多学科的，具有来自化学，材料科学和物理学领域的工具和技术。从事这项研究的研究生和本科生将获得对这些不同方法的综合理解，为他们未来的职业生涯提供强大的工具。