The Interdependence of Redox and Recognition Processes

罗特洛教授和他的同事将首先研究氧化还原开关对一些小分子(亚胺-二氨基吡啶二元组分)分子识别性能的影响。他们将使用EPR、核磁共振和密度泛函计算方法来确定控制氧化还原调制分子识别过程效率的因素。然后，他们将应用氧化还原调制识别过程来控制超分子聚合物和聚合物网络的形成。这项聚合物工作将包括开发氧化还原活性交联剂，用于表面和溶液中的电子控制交联过程和氧化还原控制聚合。通过这一奖项，有机和高分子化学项目支持马萨诸塞大学阿默斯特分校化学系文森特·M·罗特洛博士的研究。罗特洛博士和他的学生将致力于小分子的开发，这种小分子可以在电诱导下改变其识别和聚合性能。其目标是制备可操纵以电子方式改变结合对或以电子方式改变齐聚/聚合状态的材料。所开发的基于有机的分子装置将有可能在计算机或传感器中用作信息存储/交换系统。在这一跨学科工作过程中培训的学生将获得制药、聚合物和特种化学品行业所需的技能。

Professor Rotello and co-workers will initially study the effects of redox switching on the molecular recognition properties of a number of small molecules (imide-diaminopyridine dyads). They will use EPR, NMR, and density functional computational methods to determine the factors that control the efficiency of redox modulated molecular recognition processes. They will then apply redox modulated recognition process to the controlled formation of supramolecular polymers and polymer networks. This polymer work will involve development of redox active cross linkers for use in electronically controlled cross linking processes and redox controlled polymerization, both at surfaces and in solution. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Vincent M. Rotello of the Department of Chemistry at the University of Massachusetts at Amherst. Dr. Rotello and his students will work on the development of small molecules which can be electrically induced to change their recognition and polymerization properties. The goal is to prepare materials which can be manipulated to change binding partners electronically or change oligomerization/polymerization state electronically. The organic based molecular devices developed will have the potential to function as information storage/switching systems in computers or sensors. Students trained during the course of this interdisciplinary work will gain skills needed by the pharmaceutical, polymer and speciality chemicals industries.