The Interdependence of Redox and Recognition Processes

Rotello教授及其同事将首先研究氧化还原开关对一些小分子（酰亚胺-二氨基吡啶二联体）的分子识别特性的影响。 他们将使用EPR，NMR和密度泛函计算方法来确定控制氧化还原调节分子识别过程效率的因素。 然后，他们将氧化还原调节识别过程应用于超分子聚合物和聚合物网络的可控形成。 这项聚合物工作将涉及开发用于电子控制交联过程和氧化还原控制聚合的氧化还原活性交联剂，包括表面和溶液。 有了这个奖项，有机和高分子化学计划是支持博士文森特M。位于阿默斯特的马萨诸塞州大学化学系的Rotello说。 Rotello博士和他的学生将致力于开发小分子，这些小分子可以通过电诱导来改变其识别和聚合特性。 目标是制备可以被操纵以电子方式改变结合配偶体或电子方式改变低聚/聚合状态的材料。 开发的有机基分子器件将有可能用作计算机或传感器中的信息存储/交换系统。 在这个跨学科的工作过程中培训的学生将获得制药，聚合物和特种化学品行业所需的技能。

Professor Rotello and co-workers will initially study the effects of redox switching on the molecular recognition properties of a number of small molecules (imide-diaminopyridine dyads). They will use EPR, NMR, and density functional computational methods to determine the factors that control the efficiency of redox modulated molecular recognition processes. They will then apply redox modulated recognition process to the controlled formation of supramolecular polymers and polymer networks. This polymer work will involve development of redox active cross linkers for use in electronically controlled cross linking processes and redox controlled polymerization, both at surfaces and in solution. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Vincent M. Rotello of the Department of Chemistry at the University of Massachusetts at Amherst. Dr. Rotello and his students will work on the development of small molecules which can be electrically induced to change their recognition and polymerization properties. The goal is to prepare materials which can be manipulated to change binding partners electronically or change oligomerization/polymerization state electronically. The organic based molecular devices developed will have the potential to function as information storage/switching systems in computers or sensors. Students trained during the course of this interdisciplinary work will gain skills needed by the pharmaceutical, polymer and speciality chemicals industries.