Synthetic Models of Flavoenzyme Activity

黄素酶活性的合成模型

• 批准号: 9528099
• 负责人: Vincent Rotello
• 金额: $ 28.1万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9528099&HistoricalAwards=false
• 关键词: Synthetic; Models; Flavoenzyme; Activity

With funding from the Organic Dynamics Program, Professor Rotello of the University of Massachusetts-Amherst will investigate non-covalent bonding factors that influence the redox properties of flavoenzymes. For this investigation the principal investigator has prepared artificial binding sites which mimic the natural sites, but allow him to quantify the individual factors that are believed to affect the redox properties. The two major factors which are considered important are hydrogen bonding and pi stacking. Preliminary evidence suggests that the project will be successful. Understanding the details of enzymatic processes will provide scientists with the knowledge to modify paradigms and procedures for improved therapeutic drug efficacy. This project from a young investigator, if successful, will provide needed information on how flavoenzymes function. Since these enzymes are essential physiological moieties, this research has significant potential in the health related domain. These results may be useful to a broader scope of redox systems that are germane to organic materials and electronic devices.

在有机动力学项目的资助下，马萨诸塞大学阿默斯特分校的罗特洛教授将研究影响黄素酶氧化还原特性的非共价键因素。在这项研究中，首席研究人员准备了模拟自然结合部位的人工结合部位，但允许他量化据信影响氧化还原性质的个别因素。被认为重要的两个主要因素是氢键和圆周率堆积。初步证据表明，该项目将取得成功。了解酶过程的细节将为科学家提供知识来修改范例和程序，以提高治疗药物的疗效。这项来自一名年轻研究人员的项目，如果成功，将提供有关黄素酶如何发挥作用的必要信息。由于这些酶是必需的生理部分，这项研究在健康相关领域具有巨大的潜力。这些结果可能对与有机材料和电子设备密切相关的更广泛的氧化还原体系有用。