Heterophilic Adhesion and Sorting of Myelin Po Protein

髓磷脂Po蛋白的异嗜粘附和分选

• 批准号: 9319534
• 负责人: Marie Filbin
• 金额: $ 23.64万
• 依托单位: CUNY Hunter College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9319534&HistoricalAwards=false
• 关键词: Heterophilic; Adhesion; Sorting; Myelin; Po

Myelin is a multi-layered membrane that wraps around the axons of neurons, insulates them, and allows nerve conduction to take place efficiently. One protein of myelin, termed Po, behaves as an adhesion molecule and is believed to hold the layers of myelin together. In addition, Po protein has been shown to enhance the growth of a growing axon. We are investigating what precise regions of the Po molecule are involved in interaction with the neuron to promote axonal growth. Furthermore, we are beginning to characterize the component on the neuron with which Po interacts to bring about this effect. Finally, for the Po protein to function correctly it must reach its correct cellular destination. We are characterizing how the cell that makes myelin, the Schwann, directs Po to its final destination.

髓磷脂是一种多层膜，它包裹着神经元的轴突，使它们绝缘，并使神经传导有效地发生。 髓磷脂的一种蛋白质，称为Po，表现为粘附分子，并被认为将髓磷脂层保持在一起。 此外，Po蛋白已显示出增强生长轴突的生长。 我们正在研究Po分子的哪些精确区域参与与神经元的相互作用以促进轴突生长。 此外，我们开始描述Po与神经元相互作用产生这种效应的组件。 最后，为了使Po蛋白正确发挥功能，它必须到达正确的细胞目的地。 我们正在描述制造髓鞘的细胞，施旺氏细胞，是如何引导阿宝到达最终目的地的。