Synthetic and Mechanistic Studies of Organometallic Reagents

有机金属试剂的合成及机理研究

• 批准号: 9320696
• 负责人: Hans Reich
• 金额: $ 38.75万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9320696&HistoricalAwards=false
• 关键词: Synthetic; Mechanistic; Studies; Organometallic; Reagents

9320696 Reich The focus of this research is to gain a mechanistic understanding of a number of important reactions and processes in organolithium chemistry. Because the chemical properties of organolithium reagents, perhaps more than any other class of organometallic compound, are dominated by inter- and intramolecular interactions with solvents and pendant groups, the spectroscopic and reactivity studies of solvation, chelation and stereochemistry together with product, selectivity and rate studies will give a better understanding of these phenomena. Since the experiments will be carried out under the conditions and in solvents in which they are used by synthetic chemists, the studies will allow better predictability of the chemical reactions of organolithium reagents and the expansion of the applications of them. Specific projects include coordinating cosolvents (principally HMPA) and the role of ion pair structure on reactivity, chelation effects, allenyl/propargyllithium reagents, preparation and mechanism of epimerization of stereochemically defined organolithium reagents, and the lithium metalloid exchange reaction. %%% With this award the Synthetic Organic Program is supporting the research of Dr. Hans J. Reich of the Department of Chemistry at the University of Wisconsin, Madison. Professor Reich will focus his work on gaining a mechanistic understanding of a number of important reactions and processes in organolithium chemistry. Since many of these reagents play a central role in organic synthesis, especially for the very important carbon-carbon bond forming reactions, these studies will allow better predictability of the chemical reactions of organolithium reagents and an expansion of their applications. ***

小赖希9320696 本研究的重点是获得一个机制， 了解一些重要的反应和过程 有机锂化学因为化学性质 有机锂试剂，也许比任何其他类别的 有机金属化合物，主要是间和 与溶剂和侧基的分子内相互作用， 溶剂化的光谱和反应性研究， 螯合和立体化学与产物一起， 选择性和速率研究将使我们更好地理解 这些现象。因为实验将在 在使用它们的条件和溶剂中， 合成化学家，研究将允许更好地 有机锂化学反应的可预测性 试剂及其应用的拓展。 具体项目包括协调共溶剂（主要是 HMPA）和离子对结构对反应性的作用， 螯合作用，联烯基/炔丙基锂试剂， 立体化学异构化的制备及机理 定义的有机锂试剂，以及锂类金属 交换反应 %有了这个奖项，合成有机计划将支持 化学系的Hans J.赖希博士的研究， 麦迪逊的威斯康星州大学。赖希教授会 他的工作重点是获得一个机械的理解 有机锂中的一些重要反应和过程 化学.由于这些试剂中的许多在以下方面起核心作用： 有机合成，特别是对于非常重要的 这些研究将允许碳碳键形成反应 更好地预测化学反应， 有机锂试剂及其应用的拓展。 ***