Synthetic and Mechanistic Studies of Organometallic Reagents

有机金属试剂的合成及机理研究

• 批准号: 0074657
• 负责人: Hans Reich
• 金额: $ 42万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0074657&HistoricalAwards=false
• 关键词: Synthetic; Mechanistic; Studies; Organometallic; Reagents

The focus of this research is to better understand the chemistry of organolithium reagents. Major efforts will be undertaken in the following areas: the mechanism of the metal-halogen exchange and related reactions, the structure of allenyl-propargyllithium reagents, the configurational stability of chiral organolithium reagents, the effect of polar cosolvents on organolithium structure and reactivity, the nature and consequences of chelation, and the role of electrophilic catalysts and ion pair structure in organolithium reactions. The research is enhanced by the use of detailed Nuclear Magnetic Resonance (NMR) studies.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Hans J. Reich of the Department of Chemistry at the University of Wisconsin, Madison. Professor Reich will focus his work on gaining a mechanistic understanding of important reactions and processes in organolithium chemistry. The experiments will be carried out under conditions in which they are used by synthetic chemists so that the results will have direct impact on a broad array of users. The research also offers an excellent training opportunity for graduate students.

本研究的重点是更好地了解有机锂试剂的化学。 本论文的主要工作将集中在以下几个方面：金属-卤素交换反应的机理和相关反应，联烯基-炔丙基锂试剂的结构，手性有机锂试剂的构型稳定性，极性共溶剂对有机锂结构和反应活性的影响，螯合作用的性质和后果，亲电催化剂和离子对结构在有机锂反应中的作用。 通过使用详细的核磁共振（NMR）研究，该研究得到了加强。有了这个更新奖，有机和高分子化学计划支持麦迪逊威斯康星州大学化学系的Hans J.赖希博士的研究。 赖希教授将把工作重点放在对有机锂化学中重要反应和过程的机械理解上。 这些实验将在合成化学家使用的条件下进行，以便结果将对广泛的用户产生直接影响。 这项研究也为研究生提供了一个很好的培训机会。