Synthetic and Mechanistic Studies of Organometallic Reagents

本研究的重点是更好地了解有机锂试剂的化学组成。主要工作包括：金属-卤素交换和相关反应的机理，烯丙基丙烯基锂试剂的结构，手性有机锂试剂的构型稳定性，极性助溶剂对有机锂结构和反应活性的影响，络合的性质和后果，以及亲电催化剂和离子对结构在有机锂反应中的作用。通过使用详细的核磁共振(核磁共振)研究，这项研究得到了加强。有了这个更新的奖项，有机和高分子化学计划正在支持威斯康星大学麦迪逊分校化学系的汉斯·J·赖克博士的研究。赖克教授将把他的工作重点放在从机理上理解有机锂化学中的重要反应和过程。这些实验将在合成化学家使用的条件下进行，因此结果将对广泛的用户产生直接影响。这项研究也为研究生提供了一个很好的培训机会。

The focus of this research is to better understand the chemistry of organolithium reagents. Major efforts will be undertaken in the following areas: the mechanism of the metal-halogen exchange and related reactions, the structure of allenyl-propargyllithium reagents, the configurational stability of chiral organolithium reagents, the effect of polar cosolvents on organolithium structure and reactivity, the nature and consequences of chelation, and the role of electrophilic catalysts and ion pair structure in organolithium reactions. The research is enhanced by the use of detailed Nuclear Magnetic Resonance (NMR) studies.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Hans J. Reich of the Department of Chemistry at the University of Wisconsin, Madison. Professor Reich will focus his work on gaining a mechanistic understanding of important reactions and processes in organolithium chemistry. The experiments will be carried out under conditions in which they are used by synthetic chemists so that the results will have direct impact on a broad array of users. The research also offers an excellent training opportunity for graduate students.