Synthetic and Mechanistic Studies of Organometallic Reagents

大学化学系的汉斯·J·赖希教授 在麦迪逊的威斯康星州，由有机合成计划支持 对有机金属试剂的合成和机理研究。 他的研究旨在获得对一个数字的机械理解 有机锂化学中的重要反应和过程， 包括螯合作用，离子对结构对 反应性，丙二烯基的形成和潜在的相互转化， 炔丙基锂试剂，立体化学定义的性质， 有机锂试剂和锂类金属的热力学 交换反应 在有机合成项目的支持下，Hans J. 威斯康星州大学化学系的赖希说， 麦迪逊研究某些有机金属化合物的化学 化合物，带有金属-碳键的分子。 他的研究集中在 主要是有机锂化合物，它们在这两个方面都发挥着核心作用。 有机和无机化学。 锂试剂通常用于 反应形成新的碳-碳键，从而帮助建立 化合物通常具有复杂的结构， 或生物活性。 此外，它们也是常见的前体， 许多其它有机金属试剂提供了额外的机会 合成化学家。 赖希教授探索有机锂化合物 为了更好地理解这些因素， 影响其结构和化学性质，从而帮助实现 更好地预测它们的化学反应， 锂试剂的应用。

Professor Hans J. Reich, of the Department of Chemistry at the University of Wisconsin at Madison, is supported by the Organic Synthesis Program for his synthetic and mechanistic studies of organometallic reagents. His research is aimed at gaining a mechanistic understanding of a number of important reactions and processes in organolithium chemistry, including chelation effects, the role of ion pair structure on reactivity, the formation and potential interconversion of allenyl and propargyllithium reagents, the properties of stereochemically defined organolithium reagents, and the thermodynamics of the lithium metalloid exchange reaction. With the support of the Organic Synthesis Program, Professor Hans J. Reich, of the Department of Chemistry at the University of Wisconsin at Madison, studies the chemistry of certain classes of organometallic compounds, molecules bearing metal-carbon bonds. His research is focused primarily on organolithium compounds, which play a central role in both organic and inorganic chemistry. Lithium reagents are often used in reactions forming new carbon-carbon bonds and thereby helping to build up the often complex structures of compounds displaying interesting chemical or biological activity. In addition, they are also common precursors to many other organometallic reagents which provide additional opportunities to synthetic chemists. Professor Reich explores organolithium compounds in solution in order to provide a better understanding of the factors influencing their structure and chemistry, thereby helping to achieve better predictability of their chemical reactions and expanding the applications of lithium reagents.