Synthetic and Mechanistic Studies of Organometallic Reagents

有机金属试剂的合成及机理研究

• 批准号: 9703589
• 负责人: Hans Reich
• 金额: $ 40.3万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2000-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9703589&HistoricalAwards=false
• 关键词: Synthetic; Mechanistic; Studies; Organometallic; Reagents

Professor Hans J. Reich, of the Department of Chemistry at the University of Wisconsin at Madison, is supported by the Organic Synthesis Program for his synthetic and mechanistic studies of organometallic reagents. His research is aimed at gaining a mechanistic understanding of a number of important reactions and processes in organolithium chemistry, including chelation effects, the role of ion pair structure on reactivity, the formation and potential interconversion of allenyl and propargyllithium reagents, the properties of stereochemically defined organolithium reagents, and the thermodynamics of the lithium metalloid exchange reaction. With the support of the Organic Synthesis Program, Professor Hans J. Reich, of the Department of Chemistry at the University of Wisconsin at Madison, studies the chemistry of certain classes of organometallic compounds, molecules bearing metal-carbon bonds. His research is focused primarily on organolithium compounds, which play a central role in both organic and inorganic chemistry. Lithium reagents are often used in reactions forming new carbon-carbon bonds and thereby helping to build up the often complex structures of compounds displaying interesting chemical or biological activity. In addition, they are also common precursors to many other organometallic reagents which provide additional opportunities to synthetic chemists. Professor Reich explores organolithium compounds in solution in order to provide a better understanding of the factors influencing their structure and chemistry, thereby helping to achieve better predictability of their chemical reactions and expanding the applications of lithium reagents.

威斯康星大学麦迪逊分校化学系的汉斯·J·赖克教授因其有机金属试剂的合成和机理研究而得到有机合成计划的支持。他的研究旨在从机理上了解有机锂化学中的一些重要反应和过程，包括螯合效应、离子对结构对反应活性的作用、烯基锂试剂的形成和潜在的相互转化、立体化学定义的有机锂试剂的性质，以及锂类金属交换反应的热力学。在有机合成计划的支持下，威斯康星大学麦迪逊分校化学系的汉斯·J·赖克教授研究了某些类型的有机金属化合物的化学，即带有金属-碳键的分子。他的研究主要集中在有机锂化合物上，有机锂化合物在有机化学和无机化学中都发挥着核心作用。锂试剂经常用于形成新的碳-碳键的反应，从而帮助建立化合物的复杂结构，显示出有趣的化学或生物活性。此外，它们也是许多其他有机金属试剂的常见前体，这为合成化学家提供了更多的机会。Reich教授探索溶液中的有机锂化合物，以便更好地了解影响其结构和化学的因素，从而帮助实现对其化学反应的更好预测，并扩大锂试剂的应用。