Biomechanics & Electrophysiology: New Approaches to Physiological Questions

生物力学

• 批准号: 9350860
• 负责人: John Long
• 金额: $ 4.44万
• 依托单位: Vassar College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-15 至 1995-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9350860&HistoricalAwards=false
• 关键词: Biomechanics; & Electrophysiology; New; Approaches

9350860 Long The goals of this project are two-fold: (1) to introduce students to the new field of biomechanics in Animal Physiology, and (2) to expand the participation and sophistication of students in the advanced laboratory in Neurobiology. To this end, we propose to develop a data-acquisition work-station, featuring a Macintosh VX computer, a high-speed analog-to- digital board, and LabVIEW software. Unlike our current system, this workstation has programming capabilities, high sample rates, multiple channels, and adjustable gains. With six work- stations, students in Animal Physiology can design and perform experiments on the biomechanics of locomotion, feeding in invertebrates, and the dynamic power output of vertebrate muscle. These new experiments are also made possible by the addition of SVHS video equipment that allows students to record and analyze animal motions. In Neurobiology, we propose to teach the sophisticated technique of brain slice electrophysiology. Students will measure the electrical interactions of different cells in the mammalian brain using brain slice electrophysiology. By giving students the opportunity to learn advanced techniques in biomechanics and electrophysiology, we are introducing them to new ways to address questions that have puzzled, and continue to puzzle, physiologists: (1) How do animals move, feed, and what, if any, limits do muscles impose? (2) How do the cells of the nervous system "learn," respond to stress, and establish and maintain electrical membrane potentials?

9350860该项目的目标是两个方面：（1）向学生介绍动物生理学的新生物力学领域，以及（2）扩大学生在神经生物学高级实验室中的参与和成熟程度。为此，我们建议开发一个数据收购工作站，其中包含Macintosh VX计算机，高速模拟对数字板和LabView软件。与我们当前的系统不同，该工作站具有编程功能，较高的样本率，多个渠道和可调节的收益。有六个工作站，动物生理学的学生可以设计和执行有关运动生物力学，进食无脊椎动物以及脊椎动物肌肉的动态功率输出的实验。通过添加SVHS视频设备，使学生可以记录和分析动物动作，从而使这些新实验成为可能。在神经生物学中，我们建议教授脑切片电生理学的复杂技术。学生将使用大脑切片电生理学测量哺乳动物大脑中不同细胞的电相互作用。 通过让学生有机会学习生物力学和电生理学领域的先进技术，我们正在向他们介绍他们的新方法，以解决困惑并继续困惑的问题，生理学家：（1）动物如何移动，饲料，喂食，以及肌肉限制肌肉施加什么？ （2）神经系统的细胞如何“学习”，对压力做出反应，建立和维持电膜电位？