RIMI: Structural Determination, Conformation Analyses, and Kinetic Studies by NMR

9353193兰姆这项建议的目的是通过使用核磁共振技术来扩大和加强化学系的研究能力。需要一台具有二维、变温和固态能力的超导、多核、300 MHz核磁共振仪器，这将为与格林斯博罗财团研究所(班尼特学院、吉尔福德学院和北卡罗来纳大学格林斯伯勒分校)和格林斯博罗地区的行业进行长期合作研究奠定基础。300 MHz核磁共振将成为确定合成有机分子、合成配体、有机金属络合物(血蓝蛋白模型和钼络合物)和蛋白质(磷脂酶)的结构阐明和结构构象的综合研究仪器。还将对钼络合物的形成、酮-烯醇平衡和人胎盘磷脂酶A2同工酶的催化活性进行动力学研究。***

9353193 Lamb The purpose of this proposal is to expand and enhance the research capabilities in the Department of Chemistry through the use of nuclear magnetic resonance (NMR) technology. A superconducting, multinuclear, 300 MHz NMR instrument with two-dimensional, variable temperature, and solid-state capabilities is requested and will provide a base for long-term cooperative research with Greensboro Consortium Institutes (Bennett College, Guilford College, and University of North Carolina at Greensboro) and industries in the Greensboro area. The 300 MHz NMR will be an integral research instrument for determining structural elucidation and structural conformation of synthetic organic molecules, synthetic ligands, organometallic complexes (hemocyanin models and molybdenum complexes), and protein (phospholipases). Kinetic studies of molybdenum complex formation, keto-enol equilibria and the catalytic activity of the human placental phospholipase A2 isoenzyme will also be conducted. ***