Gel Release Technology: Simulation with Experimental Verification

凝胶释放技术：模拟与实验验证

• 批准号: 9361271
• 负责人: Jeffrey Sachs
• 金额: $ 6.4万
• 依托单位: DANIEL H WAGNER ASSOCIATES INCORPORATED
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9361271&HistoricalAwards=false
• 关键词: Gel; Release; Technology; Simulation; Experimental

9361271 Sachs The goal of this project is to improve the prediction and optimization of the performance of polymer gels in applications in the agricultural, pharmaceutical, and chemical production and purification industries. These improvements will be brought about by increased understanding of transport, flow, and swelling in polymer gels through: (1) elucidation of the physical phenomena fundamental to their behavior; (2) quantification of these phenomena in a mathematical model; and (3) development of an experimentally verified software tool implementing these models. Design and optimization of gel-based technologies could be significantly accelerated by this software. In Phase I, numerical computations based on a prototype model will predict gel swelling and stresses, charge density, solute concentrations, and solute and solvent fluxes. The model will be validated by comparing its predictions with an experiment on release of blue dextrans. ***

9361271 Sachs 该项目的目标是改进聚合物凝胶在农业、制药、化学生产和纯化行业应用中的性能预测和优化。 这些改进将通过增加对聚合物凝胶中的传输、流动和膨胀的理解来实现：（1）阐明对其行为至关重要的物理现象； (2) 在数学模型中量化这些现象； (3) 开发一个经过实验验证的软件工具来实现这些模型。 该软件可以显着加速基于凝胶的技术的设计和优化。 在第一阶段，基于原型模型的数值计算将预测凝胶膨胀和应力、电荷密度、溶质浓度以及溶质和溶剂通量。 该模型将通过将其预测与蓝色葡聚糖释放的实验进行比较来验证。 ***