Gel Release Technology: Simulation with Experimental Verification

9361271 Sachs该项目的目标是提高聚合物凝胶在农业、制药和化学生产和纯化行业中的应用性能的预测和优化。 这些改进将通过增加对聚合物凝胶中的运输、流动和溶胀的理解来实现，所述理解通过：（1）阐明对其行为至关重要的物理现象;（2）在数学模型中量化这些现象;和（3）开发实施这些模型的实验验证的软件工具。 该软件可以显著加快基于凝胶的技术的设计和优化。 在阶段I中，基于原型模型的数值计算将预测凝胶溶胀和应力、电荷密度、溶质浓度以及溶质和溶剂通量。 该模型将通过将其预测与蓝色葡聚糖释放实验进行比较来验证。 ***

9361271 Sachs The goal of this project is to improve the prediction and optimization of the performance of polymer gels in applications in the agricultural, pharmaceutical, and chemical production and purification industries. These improvements will be brought about by increased understanding of transport, flow, and swelling in polymer gels through: (1) elucidation of the physical phenomena fundamental to their behavior; (2) quantification of these phenomena in a mathematical model; and (3) development of an experimentally verified software tool implementing these models. Design and optimization of gel-based technologies could be significantly accelerated by this software. In Phase I, numerical computations based on a prototype model will predict gel swelling and stresses, charge density, solute concentrations, and solute and solvent fluxes. The model will be validated by comparing its predictions with an experiment on release of blue dextrans. ***