High Sensitivity Nanoprobe for Molecular Imaging

用于分子成像的高灵敏度纳米探针

• 批准号: 9361525
• 负责人: Philippe Bado
• 金额: $ 6.5万
• 依托单位: CLARK-MXR INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-15 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9361525&HistoricalAwards=false
• 关键词: Sensitivity; Nanoprobe; Molecular; Imaging

9361525 Bado This Small Business Innovation Research (SBIR) project is in the general area of surface chemistry and in the subfields of Secondary Ion Mass Spectrometry (SIMS) and Multiphoton Resonance Ionization (MPRI). The objective of the research is to fabricate and test a high- sensitivity nanoprobe with the capability of directly determining the lateral location of atoms and molecules on nonconducting surfaces with high spatial resolution (100nm) and very high sensitivity in the atomole range. The nanoprobe will combine sub-picosecond laser techniques in MPRI with focused ion beams from TOF-SIMS in surface imaging applications. During Phase I, the development of a post-ionization ultrashort pulse laser source will be emphasized. Laser source parameters will be optimized to boost nanoprobe sensitivity. A two to three order of magnitude improvement in sensitivity over systems with identical spatial resolution is anticipated. %%% There is a clear market in surface science and biology for imaging tools with sub-micron resolution and high chemical sensitivity. The proposed nanoprobe complements existing capabilities in optical and electron microscopy, provides the ability to identify chemical species with high spatial resolution, and promises to enhance our ability to image biological surfaces. ***

小行星9361525 这个小企业创新研究（SBIR）项目是在表面化学的一般领域和二次离子质谱（西姆斯）和多光子共振电离（MPRI）的子领域。该研究的目的是制造和测试一种高灵敏度纳米探针，该探针能够直接确定非导电表面上原子和分子的横向位置，具有高空间分辨率（100 nm）和原子范围内的非常高的灵敏度。纳米探针将结合联合收割机亚皮秒激光技术在MPRI与聚焦离子束从飞行时间二次离子质谱仪在表面成像应用。在第一阶段，将着重发展电离后超短脉冲激光源。将优化激光源参数以提高纳米探针的灵敏度。预计在具有相同空间分辨率的系统上灵敏度将提高两到三个数量级。 在表面科学和生物学领域，具有亚微米分辨率和高化学灵敏度的成像工具有着明确的市场。 拟议的纳米探针补充现有的光学和电子显微镜的能力，提供了高空间分辨率识别化学物种的能力，并有望提高我们的生物表面成像的能力。 ***