Behavioral Neurobiology of Stress Hormones

应激激素的行为神经生物学

• 批准号: 9410284
• 负责人: Joan Rose
• 金额: $ 20.65万
• 依托单位: University of Wyoming
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9410284&HistoricalAwards=false
• 关键词: Behavioral; Neurobiology; Stress; Hormones

IBN-9410284 James Rose In some amphibian species male courtship of females is rapidly suppressed by secretion of the steroid corticosterone in response to stressful environmental stimuli. This project will investigate the actions of stress-related steroid hormones on brain function and behavior. This species is uniquely valuable for study because its stress-sensitive reproductive behavior allows one to investigate two different actions of stress steroids on brain function: a rapid action that appears in a matter of minutes and a slowly-developing action that occurs across a period of hours. Studies of the behavior of the animal and of the electrical signals of the brain cells will help to identify the rapid and slow effects of several types of stress steroid hormones on the brain cells that control courtship behavior. The results of these studies have general significance because both rapid and slow brain effects of stress steroids are likely to be present in diverse species of animals. The findings should help to explain how environmental stressors act on the nervous system to impair reproduction in natural populations of animals and will provide a framework for understanding possible modes of stress steroid action on brain function in humans.

詹姆斯·罗斯（James Rose） 在某些两栖动物物种中，雄性对雌性的求偶行为会因应激性环境刺激而分泌类固醇皮质酮而迅速受到抑制。这个项目将研究与压力有关的类固醇激素对大脑功能和行为的作用。这个物种对研究具有独特的价值，因为它对压力敏感的生殖行为允许人们研究压力类固醇对大脑功能的两种不同作用：在几分钟内出现的快速作用和在几个小时内发生的缓慢发展的作用。对动物行为和脑细胞电信号的研究将有助于确定几种类型的应激类固醇激素对控制求偶行为的脑细胞的快速和缓慢影响。这些研究的结果具有普遍意义，因为应激类固醇对大脑的快速和缓慢影响可能存在于不同物种的动物中。这些发现应该有助于解释环境压力如何作用于神经系统，从而损害动物自然种群的繁殖，并将为理解压力类固醇对人类大脑功能作用的可能模式提供一个框架。