Simultaneous Fermentation and Metabolite Removal by Adsorption in Fungal Production of Fumaric Acid Involving Carbon Dioxide Fixation

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9412582 Tsao This project is on research to study the production of fumaric acid by Rhizopus oryzae. A procedure for removing the product by resin adsorption as it is formed in the bioreactor will be used to avoid product inhibition. In addition to developing this process, this research will also investigate the effect of oxygen supply and carbon dioxide transfer. A mathematical model based on material balances, process kinetics, and bioenergetics will be developed and used in an analysis of the process. ***