Engineering nanoscale tools for cellular interrogation

用于细胞询问的工程纳米级工具

• 批准号: FT220100749
• 负责人: A/Prof Roey Elnathan
• 金额: $ 62.24万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100749
• 关键词: Engineering; nanoscale; tools; cellular; interrogation

The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.

其目的是解决电活性纳米工具和活细胞之间的工程无缝纳米生物界面的基本障碍。预期这允许将许多生物活性货物类型有效递送到细胞中、胞质溶胶内容物的细胞内取样和动作电位的探测，所有这些都在细胞-材料界面处。新的，强大的，电活性纳米级工具，提供精确的时空分辨率和最小的侵入性和扰动可能会改变离体细胞过程。预期的结果对于最大限度地提高工程和实施离体细胞过程的精度至关重要。知识的根本进步最终可能成为开发基于细胞的疗法的平台。