Development of Water Soluble Polymeric Bifunctional AffinityLigands for Biochemical and Biomedical Applications

用于生化和生物医学应用的水溶性聚合物双功能亲和配体的开发

• 批准号: 9415683
• 负责人: Roberto Guzman
• 金额: $ 23.72万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9415683&HistoricalAwards=false
• 关键词: Development; Water; Soluble; Polymeric; Bifunctional

9415683 Guzman This project is on research to study the synthesis and development of water soluble bifunctional affinity ligands. These ligands are potentially useful for a variety of biochemical separations, as well as analytical, preparative and diagnostic applications. Soluble polymers such as polyethylene glycol (PEG) will be derivatized with two different reactive groups at two termini to obtain heterofunctional complexes with two different affinity groups. A variety of functional ligands, such as chelating agents, peptides, proteins, enzyme-substrates etc., will be synthesized and studied. Also, the recovery and reuse of these ligands will be investigated. ***

9415683 Guzman本项目是研究水溶性双功能亲和配体的合成和开发。 这些配体可用于各种生化分离，以及分析，制备和诊断应用。 可溶性聚合物如聚乙二醇（PEG）将在两个末端用两个不同的反应性基团衍生化，以获得具有两个不同亲和基团的异官能复合物。 各种功能配体，如螯合剂、肽、蛋白质、酶底物等， 将进行合成和研究。 此外，这些配体的回收和再利用将进行研究。 ***