U.S.-German Cooperative Research on the Applications of Organolanthanides in Organic Synthesis

该奖项支持科罗拉多大学博尔德分校的Gary Molander教授和柏林工业大学无机和分析化学研究所的Herbert Schumann教授之间的合作。这些研究人员将联合他们在有机和无机化学方面的不同专业知识，共同致力于有机镧系化合物和某些其他有机金属化合物的设计和合成，并探索它们在选择性有机合成中作为催化剂的用途。Schumann教授领导的团队在有机镧系元素的合成和结构测定方面是世界上最强的团队之一。它将在设计用于催化反应研究的新型有机金属配合物方面发挥主导作用，并将为制备催化剂提供实验方法。它还提供了处理空气敏感材料的重要技能。莫兰德博士领导的研究小组带来了合成有机化学方面的专业知识。美国小组将提供对重要有机反应的见解，这可能受益于德国小组生产的有机金属化合物，实际上，为有待探索的催化剂提供规格说明。他们将合成感兴趣的催化反应所需的有机底物，并进行有机反应并对其进行详细的研究。由NSF及其德国同行DFG资助的博士后研究员和高级研究生每年互访几个月，将使两个小组能够分享和转移他们在有机金属化学各个方面的专业知识。由于其不同寻常的性质，有机镧系元素为有机反应的促进剂和催化剂提供了有趣的可能性。到目前为止，合成化学家对有机镧系化合物在有机合成中的应用进行系统研究的工作还很少。现在，像舒曼博士这样的无机化学家已经成功地生产出了一系列镧系催化剂，像莫兰德博士这样的有机合成专家就有可能提出新的“设计”催化剂的特征，这些特征将大大改善特定的合成过程。因此，这次合作将为无机实验室发展的化学提供一个出口，并为在那里设计和合成的许多有机金属配合物提供实际应用的希望。＊＊＊

9422011 Molander This award supports the establishment of a collaboration between Professor Gary Molander of the University of Colorado, Boulder, and Professor Herbert Schumann of the Institute for Inorganic and Analytical Chemistry at the Technical University of Berlin. These investigators will join their diverse expertise in organic and inorganic chemistry in a joint effort focused on the design and synthesis of organolanthanides and certain other organometallic compounds, and the exploration of their use as catalysts in selective organic synthesis. The team led by Professor Schumann is one of the strongest in the world in the synthesis and structural determination of organolanthanides. It will play the lead role in designing new organometallic complexes for study in the catalytic reactions and it will provide experimental procedures to prepare the catalysts. It also provides important skills in the handling of air-sensitive materials. The research group headed by Dr. Molander brings expertise in synthetic organic chemistry. The U.S. group will provide the insights into important organic reactions which might benefit from the organometallic compounds produced by the German group, in effect, providing specifications for the catalysts to be explored. They will synthesize the organic substrates needed for the catalytic reactions of interest and carry out the organic reactions and study them in detail. Reciprocal visits of postdoctoral fellows and advanced graduate students for several months per year, funded by NSF and its German counterpart, the DFG, will enable the two groups to share and transfer their expertise in various aspects of organometallic chemistry. Because of their unusual properties, organolanthanides offer interesting possibilities as promoters and catalysts for organic reactions. Until now, there has been very little systematic work by synthetic chemists to study applications if the whole range of organolanthanides in organic synthesis. Now that inorganic chemists su ch as Dr. Schumann have succeeded in producing a range of lanthanide catalysts, it becomes possible for an expert in organic synthesis such as Dr. Molander to suggest characteristics for new "designer" catalysts that will greatly improve specific synthetic processes. Thus this collaboration will provide an outlet for the chemistry developed in the inorganic laboratory, with the promise of practical uses for the many organometallic complexes designed and synthesized there. ***