SuSChEM: GOALI: Enabling Photoredox Catalysis in the Industrial Setting

SuSChEM:目标:在工业环境中实现光氧化还原催化

基本信息

  • 批准号:
    1664818
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-15 至 2021-07-31
  • 项目状态:
    已结题

项目摘要

The Chemical Synthesis Program of the Chemistry Division supports the project by Professor Gary Molander. Professor Molander is a faculty member in the Department of Chemistry at the University of Pennsylvania. He has developed a new way of making carbon-carbon bonds. The research is of broad scientific impact since carbon-carbon bonds are used in chemicals produced by the pharmaceutical, agrochemical, fine chemical, materials, and commodity chemical (e.g., display devices, cosmetics, etc.) industries. Using this new method for making carbon-carbon bonds, the Molander group is working toward more sustainable approaches to the construction of complex molecules. Central to this method is the fact that the reactions are driven by visible light, require no heating of the chemical reaction. The reactions can also be conducted in the absence expensive, precious metals. The simple reaction conditions make the method not only more sustainable, but also more economically viable. This potential has attracted the chemical company, Novartis as a partner. Working together, Novartis and the Molander group are developing industrial applications of the new reaction methods. The project lies at the interface of organic and inorganic chemistry. With insight into industrial research provided by the project, students gain for important perspectives on the industrial job market. Outreach activities involving both academic and industrial partners in the project are targeting underrepresented groups. Photoredox/nickel dual catalysis provides a means to form new carbon-carbon bonds in new ways. This paradigm, combined with carbon-hydrogen (C-H) functionalization, provides a powerful combination for the sustainable synthesis of complex organic molecules. In the research, the following lines of inquiry are pursued: 1. Can conditions be found wherein acyl and alkyl radicals can be generated through visible light photocatalysis and engaged in nickel-catalyzed cross-coupling reactions? 2. Can intramolecular hydrogen atom transfer be controlled in a manner that allows arylation at specific sites along an alkyl chain? 3. Can the specificity be changed through polarity reversal by adding amine-boranes or NHC-boranes to the reaction mixture? 4. Can these new synthetic methods be translated to large scale synthesis using photoflow techniques with partners at Novartis? This last aspect provides outreach possibilities and translation of basic science to the industrial setting.
化学系的化学合成计划支持加里莫兰德教授的项目。莫兰德教授是宾夕法尼亚大学化学系的教员。 他发明了一种制造碳-碳键的新方法。该研究具有广泛的科学影响,因为碳-碳键用于制药、农用化学品、精细化学品、材料和商品化学品(例如,显示设备、化妆品等)行业 利用这种制造碳-碳键的新方法,莫兰德小组正在努力寻找更可持续的方法来构建复杂分子。这种方法的核心是反应由可见光驱动,不需要加热化学反应。 反应也可以在不存在昂贵的贵金属的情况下进行。简单的反应条件使该方法不仅更可持续,而且更经济可行。这种潜力吸引了化学公司诺华公司作为合作伙伴。诺华和莫兰德集团正在共同开发新反应方法的工业应用。该项目涉及有机化学和无机化学的交叉点。通过对该项目提供的工业研究的深入了解,学生可以获得工业就业市场的重要观点。 该项目的学术和工业伙伴参与的外联活动针对代表性不足的群体。 光氧化还原/镍双催化提供了以新方式形成新的碳-碳键的手段。 这种范式与碳氢(C-H)官能化相结合,为复杂有机分子的可持续合成提供了强大的组合。 在本研究中,主要进行了以下几个方面的研究:1. 能否找到条件,使酰基和烷基自由基可以通过可见光照射产生,并从事镍催化的交叉偶联反应? 2. 分子内氢原子的转移是否可以控制在烷基链上沿着的特定位置进行芳基化? 3. 通过向反应混合物中加入胺-硼烷或NHC-硼烷,可以通过极性反转改变特异性吗? 4. 这些新的合成方法能否与诺华的合作伙伴一起使用光流技术转化为大规模合成? 这最后一个方面提供了推广的可能性和基础科学的工业环境的翻译。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis
镍/光氧化还原双重催化实现脱氨基还原芳基化
  • DOI:
    10.1021/acs.orglett.9b01097
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Yi Jun;Badir Shorouk O;Kammer Lisa Marie;Ribagorda Maria;Mol;er Gary A
  • 通讯作者:
    er Gary A
Photoredox-Catalyzed Multicomponent Petasis Reaction with Alkyltrifluoroborates
光氧化还原催化的多组分与烷基三氟硼酸盐的堆积反应
  • DOI:
    10.1021/acs.orglett.9b01747
  • 发表时间:
    2019-06-21
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Yi, Jun;Badir, Shorouk O.;Molander, Gary A.
  • 通讯作者:
    Molander, Gary A.
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Gary Molander其他文献

Gary Molander的其他文献

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{{ truncateString('Gary Molander', 18)}}的其他基金

Post-Synthetic Modification of Macromolecules via Photoredox Catalysis
通过光氧化还原催化进行大分子的合成后修饰
  • 批准号:
    1952583
  • 财政年份:
    2020
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Novel Polyfluoroalkylated Building Blocks
新型多氟烷基化结构单元
  • 批准号:
    1362841
  • 财政年份:
    2014
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
GOALI: High Throughput Experimentation for Reaction Optimization
GOALI:反应优化的高通量实验
  • 批准号:
    0848460
  • 财政年份:
    2009
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Purchase of an X-ray Diffractometer
购买X射线衍射仪
  • 批准号:
    0840438
  • 财政年份:
    2009
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
U.S.-German Cooperative Research on the Applications of Organolanthanides in Organic Synthesis
美德合作研究有机镧系元素在有机合成中的应用
  • 批准号:
    9996377
  • 财政年份:
    1999
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
U.S.-German Cooperative Research on the Applications of Organolanthanides in Organic Synthesis
美德合作研究有机镧系元素在有机合成中的应用
  • 批准号:
    9422011
  • 财政年份:
    1995
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Enantioselective Organic Syntheses
对映选择性有机合成
  • 批准号:
    9005727
  • 财政年份:
    1990
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
Enantioselective Organic Syntheses (Chemistry)
对映选择性有机合成(化学)
  • 批准号:
    8704178
  • 财政年份:
    1987
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant

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