GOALI: High Throughput Experimentation for Reaction Optimization

GOALI：反应优化的高通量实验

• 批准号: 0848460
• 负责人: Gary Molander
• 金额: $ 100万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848460&HistoricalAwards=false
• 关键词: GOALI; Throughput; Experimentation; Reaction; Optimization

The GOALI project will integrate research groups at the University of Pennsylvania and members of the Merck, Rahway, Department of Process Research and the Catalytic Reactions Discovery and Development Laboratory. The focal point of this GOALI collaborative program is Merck?s High Throughput Experiments (HTE) facility, which will allow these two groups to collaborate on reaction discovery and optimization. Fundamental synthetic organic reactions of interest and importance not only to the pharmaceutical industry, but to the chemistry community as a whole will be explored to establish an inexpensive, permanent HTE facility at the University of Pennsylvania, which will in turn serve as a prototype that other academic institutions might adopt as a baseline tool for 21st century synthetic methods development.With this award, the Organic and Macromolecular Program of the Division of Chemistry is supporting the groups of Professors Jeff Bode, Marisa Kozlowski, Gary Molander, and Patrick Walsh at the University of Pennsylvania, permitting them to advance their programs in synthetic methods development. Novel, more effective and environmentally sound methods for chemical synthesis are envisioned to arise from this program ? methods that can be implemented in the pharmaceutical, agricultural, and materials sciences sectors in the US and throughout the world.

GOALI项目将整合宾夕法尼亚大学的研究小组以及默克、拉赫韦公司过程研究部和催化反应发现与开发实验室的成员。此次GOALI合作项目的焦点是默克？高通量实验（HTE）设施，这将使这两个小组在反应发现和优化方面进行合作。不仅对制药业，而且对整个化学社区都具有重要意义的基本合成有机反应将被探索，以在宾夕法尼亚大学建立一个廉价的永久性HTE设施，这将反过来作为其他学术机构可能采用的原型，作为21世纪合成方法开发的基准工具。化学部的有机和大分子项目通过这个奖项支持宾夕法尼亚大学的Jeff Bode、Marisa Kozlowski、Gary Molander和Patrick Walsh教授团队，允许他们推进他们在合成方法开发方面的项目。新的，更有效的和环保的化学合成方法被设想从这个程序产生？可以在美国和世界各地的制药，农业和材料科学部门实施的方法。