Synthesis of Heterocyclic Natural Products

本研究的重点是发展Heck反应的变种、N-亚磺酰二烯亲和型Diels-Alder方法学和催化抗体技术来合成复杂的天然产物。目标分子包括石松生物碱麦哲伦和麦哲伦酮，海洋生物碱柱状精浆蛋白和琼脂糖胺，以及天冬氨酸连接的碳水化合物。通过这个奖项，合成有机项目支持宾夕法尼亚州立大学化学系的Steven M.Weinreb博士的研究。Weinreb教授将把他的工作重点放在开发全合成具有生物学意义的复杂自然分子的方法学上。

The focus of this research is the development of variants of the Heck reaction, N-sulfinyl dienophile Diels-Alder methodology and catalytic antibody technology for the synthesis of complex natural products. Target molecules include the Lycopodium alkaloids magellanine and magellaninone, the marine alkaloids cylindrospermopsin and agelastatin and asparganine-linked carbohydrates. With this award, the Synthetic Organic Program is supporting the research of Dr. Steven M. Weinreb of the Department Chemistry at Pennsylvania State University. Professor Weinreb will focus his work on the development of methodology for the total synthesis of complex naturally occurring molecules of biological significance.