Development of new methodology for the synthesis of heterocyclic natural products

杂环天然产物合成新方法的开发

• 批准号: 341648-2010
• 负责人: Sammis, Glenn
• 金额: $ 3.64万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527407
• 关键词: Development; new; methodology; synthesis; heterocyclic

Heterocyclic compounds (cyclic compounds that contain a heteroatom such as oxygen or nitrogen) are prevalent in and integral to a number of industries, such as pharmaceuticals, flavors, fragrances, and fine chemicals. Because the vast majority of new medicinal compounds contain heterocycles, the pharmaceutical industry (which generates roughly $550 billion in annual global sales revenue), has been actively seeking new efficient and cost-effective methods for their synthesis. Any increase in synthetic efficiency can lead to both a reduction in the production cost, thus lowering the price of the medicine, and the profound environmental benefit of less chemical waste.

杂环化合物（含有杂原子如氧或氮的环状化合物）在许多工业中是普遍的并且是其组成部分，如药物、调味剂、香料和精细化学品。 由于绝大多数新的药用化合物含有杂环，因此制药行业（每年产生约5500亿美元的全球销售收入）一直在积极寻求新的高效和具有成本效益的合成方法。合成效率的任何提高都可以降低生产成本，从而降低药物的价格，以及减少化学废物的深远环境效益。