Synthesis of Heterocyclic Natural Products

本研究的重点是结构独特的多环海洋苔藓虫生物碱的chartelline/chartelamides/securamine组的全合成。 重点将放在发展创新和实用的有机合成方法，这将是用于化学家在学术界和工业界。有了这个奖项，有机和高分子化学计划是支持博士的研究。宾夕法尼亚州立大学化学系的Weinreb说。 Weinreb教授的工作重点是开发杂环和杂环海洋天然产物合成的方法和新策略。 这项工作有很大的潜力，在制药行业产生更广泛的影响，该项目作为研究生和博士后培训的一个很好的场所。

The focus of this research involves the total synthesis of the structurally unique polycyclic marine bryozoan alkaloids of the chartelline/chartelamides/securamine group. A strong emphasis will be placed on developing innovative and practical methods of organic synthesis which will be of use to chemists in both academia and industry.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Steven M. Weinreb in the Department of Chemistry at Pennsylvania State University. Professor Weinreb will focus his work on development of methodology and new strategies for the synthesis of heterocycles and heterocyclic marine natural products. The work has great potential for broader impact in the pharmaceutical industry and the project serves as an excellent venue for the training of graduate students and postdoctorals.