Developing serial crystallography for room temperature structure & dynamics

开发室温结构的系列晶体学

• 批准号: FT220100405
• 负责人: A/Prof Nadia Zatsepin
• 金额: $ 61.97万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-27 至 2027-07-26
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100405
• 关键词: Developing; serial; crystallography; room; temperature

This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bacteria. This project expects to generate new knowledge to guide the development of a new type of antibacterial to circumvent antibiotic resistance. Expected outcomes of this project include new experimental, computational and simulation tools for dynamic X-ray crystallography including new capabilities at the Australian Synchrotron for very small microcrystals of any biomolecule. This would provide a powerful new tool for the Australian structural biology community that should accelerate fundamental discoveries, including facilitating high-resolution structure determination of membrane proteins and drug development.

该项目旨在揭示细菌中负责蛋白质折叠的细菌酶的分子结构动力学。该项目预计将产生新的知识，以指导开发一种新型的抗菌剂，以规避抗生素耐药性。该项目的预期成果包括用于动态X射线晶体学的新的实验、计算和模拟工具，包括澳大利亚同步加速器用于任何生物分子的非常小的微晶的新能力。这将为澳大利亚结构生物学界提供一个强大的新工具，加速基础发现，包括促进膜蛋白的高分辨率结构测定和药物开发。