Synthesis and Characterization of Boron Containing Amino Acids

William Quintana博士，新墨西哥州州立大学化学系， 由无机，生物无机和有机化学支持 学院早期职业生涯下化学系的化学课程 合成含有硼多面体的氨基酸 开展学生直接参与的教育活动， 从而使他们对自己的发展更加负责。通过扩大 已知的氨基酸制剂，α-氨基酸的衍生物，其中 被含硼基团取代的烷基将 合成了同样地，氨基酸的α-碳原子将是 被硼原子取代以产生硼化氨基酸。这些 然后，化合物将通过各种物理和 光谱方法教育部分强调课程 在低和高本科水平的发展，并将 包括纳入示范，建立研究 组，并启动成果评估。 被修饰为与所述氨基酸略有不同的氨基酸， 天然存在的氨基酸具有许多潜在的应用。 由于修饰的氨基酸类似于天然氨基酸，它们可能 但由于它们之间的差异， 并不完全像它们的天然类似物那样起作用。因此，修改 氨基酸可用于探测或改变生物化学过程。的 该项目研究部分的目的是开发方法， 产生含有硼而不是通常的碳的新氨基酸 原子的这些具有作为酶抑制剂的潜在应用， 硼捕获中子疗法，一种正在开发的治疗方法， 癌的这个项目的研究和教育部分 旨在服务于少数民族学生的重要人口 就读于新墨西哥州州立大学。

Dr. William Quintana, Chemistry Department, New Mexico State University, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division under a Faculty Early Career Advancement Award to synthesize amino acids that contain boron polyhedra and to develop educational activities that directly involve students, thus making them more responsible for their own development. By expanding known amino acid preparations, derivatives of alpha-amino acids in which the alkyl group is substituted by a boron containing group will be synthesized. Likewise, the alpha-carbon atom of the amino acid will be replaced by a boron atom to produce boronated amino acids. These compounds then will be characterized by a variety of physical and spectroscopic methods. The educational component emphasizes course development at both the lower and upper undergraduate levels and will include the incorporation of demonstrations, the establishment of study groups, and the initiation of outcomes assessments. Amino acids which are modified to be slightly different from the naturally occurring amino acids have numerous potential applications. Because the modified amino acids resemble the natural ones, they may enter into biological systems but, because of the differences, they will not function exactly as their natural analogs. Consequently, modified amino acids can be used to probe or change biochemical processes. The purpose of the research portion of this project is to develop methods to produce new amino acids that contain boron instead of the usual carbon atoms. These have potential applications as enzyme inhibitors and in Boron Capture Neutron Therapy, a treatment being developed for some cancers. Both the research and the educational portions of this project are designed to serve the significant population of minority students enrolled at New Mexico State University.