Sensing biomechanical forces in the heart

感测心脏中的生物力学力

• 批准号: FT220100159
• 负责人: Dr Charles Cox
• 金额: $ 57.9万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100159
• 关键词: Sensing; biomechanical; forces; heart

Mechanosensitive ion channels are key molecules that define how each heart cell interacts with their physical environment. Yet how they enable cells to decode biomechanical cues remains poorly understood. At the heart of this problem is a lack of tools to quantify the force required for activation. This project aims to develop novel technologies to record the activity of these essential channels in a critical cell type within the heart, and use this information in addition to micro-engineering approaches to fully understand the role of these channels in force sensing and generation, at both the single cell and micro-tissue levels. This knowledge and technology has broad utility that extends far beyond cardiac biology into multiple fields.

机械敏感离子通道是决定每个心脏细胞如何与其物理环境相互作用的关键分子。然而，它们如何使细胞解码生物力学线索仍然知之甚少。这个问题的核心是缺乏量化激活所需力量的工具。该项目旨在开发新技术来记录心脏内关键细胞类型中这些重要通道的活动，并使用这些信息以及微工程方法来充分了解这些通道在单细胞和微组织水平上的力传感和生成中的作用。这种知识和技术具有广泛的实用性，远远超出了心脏生物学到多个领域。