Novel mechano-signalling pathways at sites of cellular adhesion

细胞粘附位点的新型机械信号传导途径

• 批准号: DP240101768
• 负责人: Dr Charles Cox
• 金额: $ 41.29万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101768
• 关键词: Novel; mechano; signalling; pathways; sites

Piezo channels are membrane proteins that detect mechanical cues and underlie our sense of touch. We aim to characterize the first protein regulator of Piezo channels by developing and utilizing novel technologies including acoustic forces to monitor Piezo channel function. The significance of this study is underscored by the wide spread expression of Piezo channels and their involvement in many cellular processes. Expected outcomes are novel technologies to study mechanobiology, patentable peptide-based Piezo modulators and a new conceptual paradigm for understanding cellular mechanosensing. This knowledge will benefit a broad scientific community through technological advancements and pharmacological agents to manipulate Piezo channels.

压电通道是一种膜蛋白，它检测机械信号并构成我们触觉的基础。我们的目标是通过开发和利用包括声学力在内的新技术来监测压电通道功能，从而表征压电通道的第一个蛋白质调节剂。压电通道的广泛表达及其参与许多细胞过程强调了这项研究的重要性。预期成果是研究机械生物学的新技术，可申请专利的基于肽的压电调制器和理解细胞机械传感的新概念范式。这些知识将通过技术进步和药理学试剂来操纵压电通道，从而使广泛的科学界受益。