Novel mechano-signalling pathways at sites of cellular adhesion

细胞粘附位点的新型机械信号传导途径

• 批准号: DP240101768
• 负责人: Dr Charles Cox
• 金额: $ 41.29万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101768
• 关键词: Novel; mechano; signalling; pathways; sites

Piezo channels are membrane proteins that detect mechanical cues and underlie our sense of touch. We aim to characterize the first protein regulator of Piezo channels by developing and utilizing novel technologies including acoustic forces to monitor Piezo channel function. The significance of this study is underscored by the wide spread expression of Piezo channels and their involvement in many cellular processes. Expected outcomes are novel technologies to study mechanobiology, patentable peptide-based Piezo modulators and a new conceptual paradigm for understanding cellular mechanosensing. This knowledge will benefit a broad scientific community through technological advancements and pharmacological agents to manipulate Piezo channels.

压电通道是膜蛋白，可检测机械提示并构成我们的接触感。我们的目的是通过开发和利用包括声学在内的新技术来监视压电通道功能，以表征压电通道的第一个蛋白质调节剂。这项研究的重要性是由压电通道的广泛扩散表达及其参与许多细胞过程的强调。预期的结果是研究机械生物学，可专利的肽压电调节剂的新技术，也是一种了解细胞机械传感器的新概念范式。这些知识将通过技术进步和药理代理来操纵压电渠道，使广泛的科学界受益。