Ultimate Sensitivity NMR of Liquids by Electron Nuclear Cross Polarization: A Pilot Study

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The frontier of sensitivity in high-resolution NMR of liquids has advanced greatly during the past 35 years. But there are still many important problems which cannot be solved by NMR because of sample concentrations falling below practical detection limits. One as yet unexploited technique for increasing sensitivity is that of electron - nuclear cross polarization in which the simultaneous saturation of an electron resonance enhances a nuclear resonance (in this case, a proton or carbon resonance). Such an experiment (essentially a simultaneous electron spin resonance and a nuclear magnetic resonance experiment) requires instrumental modifications not usually encountered in NMR (or in EPR) experiments and careful and precise manipulation of experimental conditions. Because of these extreme requirements the feasibility of such an approach must be demonstrated. Dr. Bachovchin will carry out such experiments to determine the possibility of success .