Ultimate Sensitivity NMR of Liquids by Electron Nuclear Cross Polarization: A Pilot Study

近35年来，液体高分辨率核磁共振灵敏度的前沿研究取得了很大进展。但由于样品浓度低于实际检测限，仍有许多重要问题无法通过核磁共振来解决。一种尚未开发的提高灵敏度的技术是电子-核交叉极化，其中电子共振的同时饱和增强了核共振（在这种情况下，是质子或碳共振）。这样的实验（本质上是同时进行电子自旋共振和核磁共振实验）需要对仪器进行修改，这在核磁共振（或EPR）实验中是不常见的，并且需要对实验条件进行仔细而精确的操作。由于这些极端的要求，必须证明这种方法的可行性。巴霍夫钦博士将进行这样的实验，以确定成功的可能性。

The frontier of sensitivity in high-resolution NMR of liquids has advanced greatly during the past 35 years. But there are still many important problems which cannot be solved by NMR because of sample concentrations falling below practical detection limits. One as yet unexploited technique for increasing sensitivity is that of electron - nuclear cross polarization in which the simultaneous saturation of an electron resonance enhances a nuclear resonance (in this case, a proton or carbon resonance). Such an experiment (essentially a simultaneous electron spin resonance and a nuclear magnetic resonance experiment) requires instrumental modifications not usually encountered in NMR (or in EPR) experiments and careful and precise manipulation of experimental conditions. Because of these extreme requirements the feasibility of such an approach must be demonstrated. Dr. Bachovchin will carry out such experiments to determine the possibility of success .