High-sensitivity multinuclear 600 MHz NMR for synthesis, catalysis and functional materials

新材料和分子的设计、合成和开发是能源储存、农业、健康和医学以及环境可持续塑料领域众多科学进步的核心。在所有这些情况下，一个基本要求是能够理解和准确定义这些分子的结构-这是实现这种核磁共振（NMR）光谱的最重要的分析技术之一。 尽管它能够提供对分子结构的精细洞察，但NMR受到其相当差的检测灵敏度的阻碍，这意味着需要相对大量的非常珍贵的样品进行分析，尽管这些数量并不总是可用。由于NMR提供的信息量非常高，它提供的数据可能非常复杂，难以解释。技术进步可以在这两个领域提供帮助，从而有助于分子设计的进步。检测探针的灵敏度可以通过用液氦将这些及其相关的前置放大器冷却到非常低的温度（分别为~25和85开尔文）来显著提高，如在低温探针或“冷冻探针”中。这些技术使化学家和材料科学家能够处理更小的数量，并更快速有效地收集有价值的数据。使用更强大的磁场还可以提高灵敏度，并导致检测信号的更大信号分散，从而可以研究更复杂和结构多样的分子。 配备高灵敏度冷冻探针的尖端NMR光谱仪将支持多个世界领先的化学、材料科学和物理研究小组，这些研究小组依赖于对分子结构的理解，使这些研究人员能够保持国际竞争力。它将取代已有十五年历史的现有核磁共振仪器，并将为采用该技术的科学家提供更大的能力、更好的性能、更高的效率和更高的可靠性。这反过来又将有助于发现与新疗法和药物（包括抗生素）相关的发现，以改善医疗保健，提高粮食生产率的先进农用化学品，用于储能的电池技术，可持续聚合物和塑料，以及未来制造的更有效方法。

The design, synthesis and development of new materials and molecules sits at the core of numerous scientific advances in energy storage, agriculture, health and medicine, and environmentally sustainable plastics. In all these cases a fundamental requirement is to be able to understand and accurately define the structure of these molecules- one of the most important analytical techniques to achieve this Nuclear Magnetic Resonance (NMR) Spectroscopy. Despite its ability to provide exquisite insights into molecular structures, NMR is hampered by its rather poor detection sensitivity, meaning relatively large quantities of very precious samples are required for analysis, although such quantities are not always available. It is also the case that due to the very high information content provided by NMR, the data it provides can be complex and challenging to interpret. Technological advances can assist in both these areas and so aid in the advancement of molecular design. The sensitivity of the detection probes can be improved significantly by cooling these and their associated preamplifiers to very low temperatures (~25 and 85 Kelvin respectively) with liquid helium, as in cryogenic probes or "cryoprobes". These enable chemists and materials scientists to work with far smaller quantities and collect valuable data more rapidly and efficiently. The use of more powerful magnetic fields also improves sensitivity and leads to greater signal dispersion of the detected signals, allowing the study of more complex and structurally diverse molecules. The cutting-edge NMR spectrometer equipped with a high-sensitivity cryoprobe will support multiple world-leading research groups across chemistry, materials science, and physics that rely on an understanding of molecular structures, enabling these researchers to remain internationally competitive. It will replace an existing NMR instrument that is fifteen years old and will provide scientists employing this technique with greater capabilities, better performance, increased efficiency and improved reliability. This in turn will enable discoveries relevant to new therapeutics and pharmaceuticals (including antibiotics) for better healthcare, advanced agrochemicals for food productivity, battery technologies for energy storage, sustainable polymers and plastics, and more efficient methods for future manufacturing.