Chemistry and Biology of Ecdysis-Triggering Hormones

蜕皮触发激素的化学和生物学

• 批准号: 9514678
• 负责人: Michael Adams
• 金额: $ 20.75万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9514678&HistoricalAwards=false
• 关键词: Chemistry; Biology; Ecdysis; Triggering; Hormones

Adams 9514678 Insect growth and development is associated with repeated shedding of the old exoskeleton or cuticle in a process called ecdysis. The successful performance of this complex behavior is crucial to the survival of developing insects. It appears that a newly described novel endocrine system regulates ecdysis in moths and may be important to this develomental process in all insects. This novel endocrine system appears to produce multiple hormones. The identification of these hormones is paramount to Dr. Adams' research endeavor. Once these factors have been chemical identified, reagents will be prepared that allow the localization and quantification of the hormones in the insect during development. Finally, the site and mechanism of ecdysis-triggering hormone action will be elucidated. This unique endocrine system provides opportunities to study the hormonal regulation of development and behavior from the molecular to the organismal level including information regarding the regulation of hormone sythesis, release and physiological action. Furthermore, premature administration of ecdysis-triggering hormone to early stages of larvae and pupae is lethal, these hormones may prove to be of great commercial significance in the biological control of insect pests.

亚当斯9514678 昆虫的生长和发育与蜕皮过程中旧的外骨骼或角质层的反复脱落有关。 这种复杂行为的成功表现对发育中的昆虫的生存至关重要。 看来，一个新的内分泌系统调节蛾蜕皮，并可能是重要的，这在所有昆虫的发育过程。 这种新的内分泌系统似乎产生多种激素。 这些激素的鉴定对亚当斯博士的研究奋进至关重要。 一旦这些因子被化学鉴定，将制备试剂，允许在发育期间定位和定量昆虫中的激素。 最后，将阐明蜕皮触发激素作用的部位和机制。 这种独特的内分泌系统提供了从分子到生物体水平研究发育和行为的激素调节的机会，包括有关激素合成，释放和生理作用调节的信息。 此外，过早地将蜕皮触发激素施用到幼虫和蛹的早期阶段是致命的，这些激素在害虫生物防治中可能被证明具有重要的商业意义。