Collaborative Research: Biotransformations Near and Above 100C: Hyperthermophilic Microorganisms and Enzymes for Bioenergy Conversion
合作研究:100C 附近及以上的生物转化:用于生物能源转化的超嗜热微生物和酶
基本信息
- 批准号:0617235
- 负责人:
- 金额:$ 42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-15 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0617235AdamsIdentification of microorganisms and biocatalysts for bioenergy conversion processes remains a key objective in the development of alternative fuels. Recently available genomics-based approaches offer unprecedented access to novel enzymes and pathways for biomass conversions. The objective of this research is to identify novel biocatalytic and metabolic strategies for bioenergy conversion by using functional and structural genomics-based methods, in conjunction with microbial and biochemical approaches. The intellectual merit of the proposed research is the strategic use of classical and modern approaches to study extremophile biology and biotechnology as this relates to bioenergy conversion. The specific objectives of the project are: (1) to use whole genome transcriptional response analyses of four hyperthermophilic hydrogen-producing anaerobes to identify novel biocatalyst targets for processing biomass to substrates that can be readily converted to biofuels; (2) to produce key biocatalysts for biochemical characterization and to assess their roles in bioenergy production; (3) to compare hydrogen production rates and yields for the four hyperthemophilic anaerobes. (4) to evaluate bioprocess strategies for biohydrogen production at elevated temperatures by hyperthermophile cultures. The broader impact of this work relates to the interdisciplinary training of graduate students in the use of functional genomics for studying biocatalysis and biotransformations in extremophilic microorganisms. The two participating laboratories will continue their longstanding efforts to involve undergraduate students and students from underrepresented minority groups in the research.
[06:17 . 35]鉴别用于生物能源转化过程的微生物和生物催化剂仍然是开发替代燃料的关键目标。最近可用的基于基因组学的方法为生物质转化提供了前所未有的新酶和途径。本研究的目的是利用基于功能和结构基因组学的方法,结合微生物和生化方法,确定新的生物催化和代谢策略,用于生物能量转换。所提议的研究的智力价值是战略性地使用经典和现代方法来研究极端微生物生物学和生物技术,因为这与生物能量转换有关。该项目的具体目标是:(1)利用四种超嗜热产氢厌氧菌的全基因组转录响应分析,确定新的生物催化剂靶点,将生物质加工成可以很容易转化为生物燃料的底物;(2)生产用于生化表征的关键生物催化剂,并评估其在生物能源生产中的作用;(3)比较四种超嗜热厌氧菌的产氢速率和产氢量。(4)评价超嗜热培养在高温下产氢的生物工艺策略。这项工作的更广泛的影响涉及到研究生在使用功能基因组学研究极端微生物的生物催化和生物转化方面的跨学科培训。这两个参与的实验室将继续他们长期以来的努力,让本科生和来自未被充分代表的少数群体的学生参与研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Adams其他文献
The scoring of cardiac events during sleep.
睡眠期间心脏事件的评分。
- DOI:
10.5664/jcsm.26816 - 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
S. Caples;C. Rosen;W. Shen;A. Gami;W. Cotts;Michael Adams;P. Dorostkar;K. Shivkumar;V. Somers;T. Morgenthaler;E. Stepanski;C. Iber - 通讯作者:
C. Iber
PD54-06 CADAVERIC EVIDENCE THAT MIDURETHRAL SLING PLACEMENT INTERRUPTS PERIURETHRAL NEUROVASCULAR AND GLANDULAR STRUCTURES: POTENTIAL ROLE IN FEMALE SEXUAL DYSFUNCTION
- DOI:
10.1016/j.juro.2018.02.2614 - 发表时间:
2018-04-01 - 期刊:
- 影响因子:
- 作者:
Dionne Gaudet;Diandra Clohosey;Johanna Hannan;Sue Goldstein;Nicole Szell;Barry Komisaruk;Marie-Andrée Harvey;Shawna Johnston;Michael Kawaja;Nader Ghasemlou;Leslie MacKenzie;Irwin Goldstein;Michael Adams - 通讯作者:
Michael Adams
Numerical analysis of contact electrification of non-spherical particles in a rotating drum
- DOI:
10.1016/j.powtec.2015.05.050 - 发表时间:
2015-11-01 - 期刊:
- 影响因子:
- 作者:
Chunlei Pei;Chuan-Yu Wu;Michael Adams - 通讯作者:
Michael Adams
P809: Diagnosis and management of pregnant people with inborn errors of metabolism in an adult reproductive genetics and genomics clinic
- DOI:
10.1016/j.gimo.2024.101717 - 发表时间:
2024-01-01 - 期刊:
- 影响因子:
- 作者:
Asha Talati;Emily Hardisty;Madeline Dyke;Clara Hildebrandt;Michael Adams;Muge Calikoglu;Neeta Vora - 通讯作者:
Neeta Vora
Net versus relative impacts in public policy automation: a conjoint analysis of attitudes of Black Americans
- DOI:
10.1007/s00146-024-01975-3 - 发表时间:
2024-07-13 - 期刊:
- 影响因子:4.700
- 作者:
Ryan Kennedy;Amanda Austin;Michael Adams;Carroll Robinson;Peter Salib - 通讯作者:
Peter Salib
Michael Adams的其他文献
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{{ truncateString('Michael Adams', 18)}}的其他基金
Dispersion and Dissolution of Hydrocolloids
亲水胶体的分散和溶解
- 批准号:
EP/W029065/1 - 财政年份:2023
- 资助金额:
$ 42万 - 项目类别:
Research Grant
Discrete computational modelling of twin screw granulation
双螺杆造粒的离散计算模型
- 批准号:
EP/M02959X/1 - 财政年份:2015
- 资助金额:
$ 42万 - 项目类别:
Research Grant
COLLABORATIVE RESEARCH: Exploiting microbial hyperthermophilicity to produce an industrial chemical
合作研究:利用微生物的超嗜热性来生产工业化学品
- 批准号:
1264053 - 财政年份:2013
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
OPTICALLY-INJECTED MULTI-SECTION LASERS FOR CHAOTIC ENCRYPTION SYSTEMS
用于混沌加密系统的光注入多段激光器
- 批准号:
EP/D078628/1 - 财政年份:2006
- 资助金额:
$ 42万 - 项目类别:
Research Grant
LSAMP - Peach State Louis Stokes Alliance for Minority Participation
LSAMP - 桃州路易斯斯托克斯少数族裔参与联盟
- 批准号:
0503278 - 财政年份:2005
- 资助金额:
$ 42万 - 项目类别:
Cooperative Agreement
Collaborative Research: Biotransformations Near and Above 100?C: Mining Genomes of Hyperthermophiles for New Biocatalysts
合作研究:接近和高于 100°C 的生物转化:挖掘超嗜热菌基因组以获取新的生物催化剂
- 批准号:
0317911 - 财政年份:2003
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
A Functional Genomics Study of the Primary Pathways for Carbon Metabolism in a Hyperthermophilic Archaeon
超嗜热古菌碳代谢主要途径的功能基因组学研究
- 批准号:
0129841 - 财政年份:2002
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
Biotransformations Near and Above 100 Degrees Celsius
接近或高于 100 摄氏度的生物转化
- 批准号:
0004257 - 财政年份:2000
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
Structure and Function of Iron-Hydrogenases in a Hyperthermophilic Bacterium and of an Analogous Protein in Higher Eukaryotes
超嗜热细菌中铁氢化酶和高等真核生物中类似蛋白质的结构和功能
- 批准号:
9904624 - 财政年份:1999
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
U.S.-Germany Cooperative Research: Restoration Ecology of the Elbe River and Its Floodplain Forests
美德合作研究:易北河及其漫滩森林的恢复生态学
- 批准号:
9901214 - 财政年份:1999
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
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