Stereoselective Hydrogenation of Pheromone Precursor Alkynes

这是与哈萨克斯坦共和国科学院有机催化和电化学研究所的A. M. Pak教授的合作。这项工作的目的是控制长链乙炔加氢产生的烯烃异构体的立体特异性。研究了铜和铜钯浸渍在氧化铝、氧化镁或二氧化硅上的立体选择性与分散性和表面酸度的关系。金属交换沸石也可用作催化剂。量子化学（CNDO/2）计算用于指导可能显示所需选择性的条件和催化剂的选择。乙炔（炔）的立体选择性还原在许多系统中都是有价值的，包括单体和从风味增强剂到抗生素的各种生物活性分子的生产。本研究制备了对昆虫防治有用的信息素前体。

ABSTRACT Alvin Weiss This is collaboration with Professor A. M. Pak of the I nstitute of Organic Catalysis and Electrochemistry of the Academy of Sciences of the Republic of Kazakhstan. The goal of this work is to control the stereospecifity of olefin isomers produced by the hydrogenation of long-chain acetylenes. Copper and copper-palladium impregnated on alumina, magnesia, or silica are studied and stereoselectivity is correlated with dispersion and surface acidity. Metal-exchange zeolites are also used as catalysts. Quantum chemical (CNDO/2) calculations are used to guide selection of conditions and catalysts that might show the desired selectivity. Stereoselective reduction of acetylenes (alkynes) is valuable for a number of systems including production of monomer and a wide variety of biologically active molecules from flavor ehancers to antibiotics. In the present study, the precursors of pheromones useful for insect control are prepared.