STTR: Molecular Force Detection

STTR：分子力检测

• 批准号: 9523179
• 负责人: Eric Henderson
• 金额: $ 10万
• 依托单位: BIOFORCE NANOSCIENCES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9523179&HistoricalAwards=false
• 关键词: STTR; Molecular; Force; Detection

9523179 Henderson This research is to develop BioTips, biologically functionalized force transducers for molecular detection. The fundamentals for the development of the BioTip are derived from the atomic force microscope. A BioTip is formed by covalently coupling biomolecules, in this case a protein/DNA pair, to cantilevers, a technology derived from the atomic force microscope. Interactions between these molecules will cause the cantilever to bend and will be detected by a laser system. Research will also be done to develop specialized molecular force detection devices by testing other molecular pairs. BioTips have enormous potential for success in industry due to its molecular force detection capabilities. When developed completely, this detection device will have a wide range of applications including chemical screening and clinical environmental diagnostics.

这项研究是开发BioTips，用于分子检测的生物功能化力传感器。开发BioTip的基本原理来源于原子力显微镜。BioTip是由共价偶联生物分子（在这种情况下是蛋白质/DNA对）与悬臂梁形成的，这是一种源自原子力显微镜的技术。这些分子之间的相互作用将导致悬臂弯曲，并将被激光系统检测到。还将研究通过测试其他分子对来开发专门的分子力检测设备。由于其分子力检测能力，BioTips在工业上具有巨大的成功潜力。一旦开发完成，该检测设备将具有广泛的应用范围，包括化学筛选和临床环境诊断。