Generation of human progenitor T cells with immune-reconstituting potential

具有免疫重建潜力的人类祖T细胞的产生

• 批准号: 230933
• 负责人: Zuniga-Pflucker Juan C
• 金额: $ 32.02万
• 依托单位: Sunnybrook Research Institute (Toronto, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=230933&lang=en
• 关键词: Hiv; Immune Reconstitution; Notch; Stem Cells; T Cells; Thymus

Individuals infected with HIV undergo a severe depletion of their T cell compartment, resulting in a state of immune deficiency. T cells are white blood cells that come from bone marrow progenitor cells and develop within a specialized organ, the thymus.

感染HIV的个体经历T细胞区室的严重消耗，导致免疫缺陷状态。T细胞是来自骨髓祖细胞的白色血细胞，在一个专门的器官胸腺中发育。