Separations and Structures Throughout the Chemistry Curriculum: GC/MS

整个化学课程中的分离和结构：GC/MS

• 批准号: 9551027
• 负责人: Jeffrey Hansen
• 金额: $ 2.78万
• 依托单位: DePauw University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9551027&HistoricalAwards=false
• 关键词: Separations; Structures; Throughout; Chemistry; Curriculum

The concepts of separations and structure are enhanced in the chemistry curriculum at all levels by the purchase of a GC/MS. The GC/MS allows the study of more interesting and relevant topics (such as pesticides in the environment or drug testing), making chemistry more accessible to a wider range of students. Use of the GC/MS provides chemistry majors with experience in an increasingly important technique. These goals are achieved by beginning with simple experiments in General Chemistry that are designed to provide the students with training on the GC/MS while demonstrating the power of its analytical capabilities. Students analyze compounds extracted from candy or chewing gum and identify the major flavorants. The concepts of atomic structure are reinforced by studying the natural distribution of isotopes. In Organic Chemistry, students use the GC/MS in a more sophisticated manner when they obtain data to study the linear free energy relationship in the fragmentation of substituted benzophenones and acetophenones. This experiment reinforces the concepts of inductive and resonance effects that are discussed in class. They also use the GC/MS to obtain kinetic data for the free radical chlorination reaction. These experiments underscore to the students and help them better understand the importance of kinetics and thermodynamics in the study of organic reaction mechanisms. In Analytical Chemistry, students learn the special consequences of using a hyphenated technique to quantitatively analyze trace levels of organics. Students continue to use the GC/MS in upper-level courses to study the structure of compounds, to study the separation of complex mixtures, and to obtain data for the study of reaction mechanisms. The instrument enhances special topics courses and student research projects.

通过购买气相色谱/质谱仪，分离和结构的概念在各级化学课程中得到加强。GC/MS允许研究更有趣和相关的主题（如环境中的农药或药物测试），使化学对更广泛的学生更容易接触。GC/MS的使用为化学专业的学生提供了越来越重要的技术经验。这些目标是通过普通化学中的简单实验来实现的，这些实验旨在为学生提供GC/MS的培训，同时展示其分析能力的力量。学生分析从糖果或口香糖中提取的化合物，并识别主要的调味剂。通过研究同位素的自然分布，加强了原子结构的概念。在有机化学中，学生在获取数据时使用更复杂的GC/MS来研究取代二苯甲酮和苯乙酮碎片中的线性自由能关系。这个实验强化了课堂上讨论的感应和共振效应的概念。他们还利用GC/MS获得了自由基氯化反应的动力学数据。这些实验强调并帮助学生更好地理解动力学和热力学在有机反应机理研究中的重要性。在分析化学中，学生学习使用连字符技术定量分析痕量有机物的特殊后果。在高级课程中，学生继续使用GC/MS来研究化合物的结构，研究复杂混合物的分离，并获得研究反应机理的数据。该工具增强了专题课程和学生研究项目。