Acquisition of Wide Bore Nuclear Magnetic Resonance Imager

小行星9601691 圣母大学将购买一台磁共振成像仪（MRI），用于生物科学、化学和生物化学、化学工程、电气工程和物理系的研究。 研究问题包括泡沫的演变，它们的结构和它们的流变学的时间依赖性的研究;包括多孔介质中的泡沫的液体的流动;在浓悬浮液中的流动的成像和它们的性质;作为这些网络的数学建模的信息源的神经网络的结构;作为厌氧和代谢改变的研究的冬眠心肌和延胡索酸还原酶;选择性MRI造影剂的设计以及作为代谢反应的组织冷冻和冷冻保护剂分布的研究。 从这些研究中获得的结果将支持电气工程系OLISAO计划的研究，该计划开发理论和数值模拟来拟合和处理图像信号。 这些研究从理论到应用，从工程设计到神经生物学。 丽莎的支持将有助于开发改进的成像技术，并提高将数据处理成图像的速度和准确性。 所提出的研究要么需要对准备好的样品进行静态成像，要么需要研究图像随时间的变化。 这些项目都可以充分执行与垂直，高分辨率核磁共振成像光谱仪在300兆赫（7特斯拉磁场）与必要的配件，以获取和处理数据。 体内探针（64 mm工作直径）将在20 G/cm（40 A）的梯度强度下监测1H，适用于青蛙的高分辨率3-D成像实验和大规模流体力学实验。 微成像探针将可用于各种核的0.4 cm至2.5 cm线圈，微成像探针的分辨率低于100 um，用于高分辨率材料科学和生物化学实验。 一些硬件和软件将需要为个别实验定制设计。 三名核磁共振专家将在核磁共振设施，一个专门致力于MRI和一个具有丰富的MRI经验，为实验开发和执行提供支持。 目前的提案包括10名教师，5名博士后，12名研究生和5名本科生研究人员。 MRI还将用于本科课程，招生人数约为65人，研究生课程每年招生人数约为25人。 ***

9601691 Glazier The University of Notre Dame will purchase a Magnetic Resonance Imaging (MRI) to pursue research in the department of Biological Sciences, Chemistry and Biochemistry, Chemical Engineering, Electrical Engineering and Physics. Research problems include the study of the evolution of foams, their structures and the time dependence of their rheology; the flow of liquids including foams in porous media; the imaging of flow in concentrated suspensions and their properties; the architecture of neural network as a source of information for the mathematical modeling of these networks; hibernating myocardium and fumarate reductase as a study of anaerobiosis and metabolic alteration; the design of selective MRI contrast agents and studies of tissue freezing and cryoprotectant distribution as a metabolic response. The results obtained from these studies will support the research of the OLISAO program in the Department of Electrical Engineering which develops theory and numerical simulations to fit and process image signals. These studies vary from theoretical to applied and form engineering design to neurobiology. The support from LISA will aid in developing improved imaging technology and increase speed and accuracy in processing of data into images. The proposed studies either require static imaging of prepared samples or study of the changes of images in time. These projects can all be adequately performed with a vertical, high resolution NMR imagine spectrometer operating at 300 MHz (7 Tesla magnetic field) with the necessary accessories to acquire and process data. The in-vivo probe (64mm working diameter) will monitor 1H at gradient strengths of 20 G/cm (at 40 A), suitable for high resolution 3-d imaging experiments on frog and for large scale hydrodynamics experiments. The microimaging probe will be available with 0.4 cm to 2.5 cm coils for various nuclei, with microprobes for microimaging at a resolution below 100 um for use in high resolution materials science and bioc hemistry experiments. Some of the hardware and software will require custom design for individual experiments. Three NMR specialists will be present in the NMR facility, one devoted solely to MRI and one with extensive MRI experience, to provide support for experiment development and execution. The current proposal includes 10 faculty, 5 postdoctoral, 12 graduate students and 5 undergraduate researchers. MRI will also be used in undergraduate courses with an enrollment of about 65 and graduate courses with an annual enrollment of about 25. ***