Acquisition of NMR Instrumentation to Upgrade the NMR Services Facility at the University of South Carolina

9601723 Reger University of南卡罗来纳州哥伦比亚大学学术研究基础设施（ARI）计划的这一奖项将帮助哥伦比亚的南卡罗来纳州大学化学生物化学系升级现有的500 MHz NMR光谱仪并获得图形工作站。这些设备将加强若干领域的研究，包括：（1）高核度混合金属簇合物的催化性能（2）过渡金属簇合物催化含硫杂环开环齐聚反应的研究（3）天然产物的研究，特别是从来自象牙海岸的四种不同树木中分离药用活性化合物（4）共价交联的DNA发夹的结构研究（5）小分子DNA结合剂，（6）模型配合物的合成及金属NMR研究。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，获得最先进的NMR是必不可少的。这些NMR研究的结果在聚合物、催化和生物学等领域都很有用。

9601723 Reger University of South Carolina Columbia This award from the Academic Research Infrastructure (ARI) Program will assist the Department of Chemistry & Biochemistry at the University of South Carolina at Columbia upgrade the existing 500 MHz NMR spectrometer and aquire a graphics workstation. This equipment will enhance research in a number of areas including the following: (1) catalytic properties of high nuclearity mixed metal cluster complexes (2) studies of the catalytic ring opening cyclooligomerization of sulfur-containing heterocycles by transition metal cluster compounds (3) investigations of natural products, specifically the isolation of medicinally active compound(s) from four different trees from the Ivory Coast (4) structural studies of covalently cross-linked DNA hairpins (5) small-molecule DNA-binding agents, and (6) syntheses and metal NMR studies of model complexes. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to a state-of-the-art NMR is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.