Acquisition of NMR Instrumentation to Upgrade the NMR Services Facility at the University of South Carolina

9601723南卡罗来纳大学哥伦比亚分校该奖项来自学术研究基础设施(ARI)计划，将帮助南卡罗来纳大学哥伦比亚分校的化学与生物化学系升级现有的500兆赫兹核磁共振波谱仪，并获得一个图形工作站。这台设备将加强以下领域的研究：(1)高核度混合金属簇合物的催化性能(2)过渡金属簇合物催化含硫杂环齐聚的研究(3)天然产物的研究，特别是从象牙海岸四种不同树木中分离出具有药用活性的化合物(S)(4)共价交联脱氧核糖核酸发夹的结构研究(5)小分子脱氧核糖核酸结合剂，以及(6)模型配合物的合成和金属核磁共振研究。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

9601723 Reger University of South Carolina Columbia This award from the Academic Research Infrastructure (ARI) Program will assist the Department of Chemistry & Biochemistry at the University of South Carolina at Columbia upgrade the existing 500 MHz NMR spectrometer and aquire a graphics workstation. This equipment will enhance research in a number of areas including the following: (1) catalytic properties of high nuclearity mixed metal cluster complexes (2) studies of the catalytic ring opening cyclooligomerization of sulfur-containing heterocycles by transition metal cluster compounds (3) investigations of natural products, specifically the isolation of medicinally active compound(s) from four different trees from the Ivory Coast (4) structural studies of covalently cross-linked DNA hairpins (5) small-molecule DNA-binding agents, and (6) syntheses and metal NMR studies of model complexes. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to a state-of-the-art NMR is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.