MRI: Acquisition of NMR spectroscopic instrumentation at Syracuse University

MRI：在雪城大学购买 NMR 光谱仪器

• 批准号: 1229345
• 负责人: Karin Ruhlandt-Senge
• 金额: $ 32.55万
• 依托单位: Syracuse University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229345&HistoricalAwards=false
• 关键词: MRI; Acquisition; NMR; spectroscopic; instrumentation

With this award from the Major Research Instrumentation (MRI) and support from the Chemistry Research Instrumentation and Facilities (CRIF) Programs Professor Karin Ruhlandt-Senge from Syracuse University and colleague Philip Borer will acquire a highly automated 400 MHz NMR spectrometer with a liquid-nitrogen cooled probe. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) reactivity, weak interactions, and aggregation in highly reactive metal species; (b) development of polysaccharide-based carriers for targeted drug delivery; (c) nucleic acid switches; (d) inhibitors of SHIP-phosphatase; (e) chiral catalysts for use in complex molecule synthesis; (f) role of metal ions in biology and medicine; (g) bioactive peptides and peptide sensors; (h) unnatural molecules with unique folds; (i) dynamic ligand exchange at quantum dot interfaces; (j) carbon-carbon bond forming reaction of 2-methylenetetrahydropyrans; and (k) technetium and rhenium-based radiopharmaceuticals.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. Many research projects associated with this application will have a direct impact on society, as they aim to develop biomimetic polymerization initiators, sensors, conducting materials, and new drugs or treatments, vaccines, amongst others. This instrument will be an integral part of teaching as well as research at Syracuse University and also at neighboring institutions.

凭借主要研究仪器 (MRI) 的这一奖项以及化学研究仪器和设施 (CRIF) 项目的支持，雪城大学的 Karin Ruhlandt-Senge 教授和同事 Philip Borer 将购买一台带有液氮冷却探头的高度自动化的 400 MHz NMR 波谱仪。该提案旨在加强各级研究培训和教育，特别是在以下领域：(a) 高反应性金属物质的反应性、弱相互作用和聚集； (b) 开发用于靶向药物递送的多糖载体； (c)核酸开关； (d) SHIP-磷酸酶抑制剂； (e) 用于复杂分子合成的手性催化剂； (f) 金属离子在生物学和医学中的作用； (g) 生物活性肽和肽传感器； (h) 具有独特折叠的非天然分子； (i) 量子点界面处的动态配体交换； (j)2-亚甲基四氢吡喃的碳-碳键形成反应； (k) 锝和铼基放射性药物。核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。许多与该应用相关的研究项目将对社会产生直接影响，因为它们的目标是开发仿生聚合引发剂、传感器、导电材料以及新药物或治疗方法、疫苗等。该仪器将成为雪城大学和邻近机构教学和研究的一个组成部分。