Development of EB/TOF Mass Spectrometer with CID and SID Capabilities

学术研究基础设施（ARI）计划的这一奖项将 协助亚利桑那大学化学系获得 具有电扇区（E）-磁混合质谱仪（MS） 扇区（B）/弯曲场反射飞行时间（TOF）几何形状。这 这些设备将加强一些领域的研究，包括 主要内容如下：（1）设计合成多种生物活性 线性和环状肽、假肽、肽模拟物和复合物 肽库（2）结构/物理性质/反应性 血红素和血红素蛋白的关系（3）酶和血红素蛋白的研究 化合物，模仿的钼和血红素中心的功能， 酶（4）新有机化合物的合成与表征（5） 基于碳水化合物的天然产物类似物的合成以及 新型碳水化合物基材料的开发（6）设计和 形成有序组装体的新型两亲分子的合成 （7）新的有机合成方法，以合成 新材料;（8）昆虫脂质转运机制。 质谱（MS）是用于探测紧密结构的技术， 详细信息，并获得大量的分子组成， 有机、生物有机和有机金属分子。的加入 电喷雾技术将质谱的范围扩展到蛋白质和核酸 酸的分子量远远超过任何其他技术。使用 电喷雾电离结合高分辨率提供了 质谱分析的最新技术。 它为化学家提供了 一个最强大的工具，可用于表征 化合物.在质谱分析中获得这种能力是 对许多领域的前沿研究至关重要， 化学.

This award from the Academic Research Infrastructure (ARI) Program will assist the Department of Chemistry at the University of Arizona acquire a hybrid mass spectrometer (MS) with an electric sector (E)-magnetic sector(B)/curved field reflection time-of-flight (TOF) geometry. This equipment will enhance research in a number of areas including the following: (1) design and synthesis of a variety of biologically active linear and cyclic peptides, pseudopeptides, peptidomimetics and complex peptide libraries (2) structure/physical property/reactivity relationships in hemes and heme proteins (3) studies of the enzyme and compounds that mimic features of the molybdenum and heme centers of the enzyme (4) synthesis and characterization of new organic compounds (5) synthesis of carbohydrate based natural product analogs and the development of novel carbohydrate based materials (6) design and synthesis of novel amphiphilic molecules that form organized assemblies upon solvation (7) novel organic snthesis methodology to synthesis of novel materials, and (8) mechanism of lipid transport in insects. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.