Transitions in Bulk and Mesoscopic Liquids

块体和介观液体的转变

• 批准号: 9602884
• 负责人: C. Austen Angell
• 金额: $ 1.99万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9602884&HistoricalAwards=false
• 关键词: Transitions; Bulk; Mesoscopic; Liquids

9602884 C. Austen Angell "Transitions in Bulk and Mesoscopic Liquids" This award will provide partial support for three months of a six month visit to the University of Sydney, Australia, by Professor C. Austen Angell of the Department of Physics, Arizona State University. Professor Angell will conduct collaborative research with Professors P. Harrowell and G. Warr on current aspects of the dynamics and thermodynamics of the glass transition, or polyamorphism glassy and liquid systems, and of the relation of such polyamorphism to major structural transitions in mesoscopic systems such as protein and RNA folding transitions. Angell's interest in glass transition phenomenology will be combined with Harrowell's theoretical expertise in kinetic Ising models, and the consequent microscopic origins of liquid fragility, and Warr's experience in microemulsion structure and stability, to improve current understanding of glasses and polyamorphism in glasses and biopolymers. The investigators will 1) use control of system size at constant chemical potential to see system size effects, in particular in systems with dimensions comparable to those attributed to microheterogeneities which now seem to appear near the glass temperature; 2) perform theoretical studies based on a facilitated spin microheterogeneous model to determine the conditions necessary to produce the smeared-out, glass- liquid transformation characteristic of hydrated protein systems; 3) undertake multi-step calorimetric studies of protein refolding kinetics to assess the relevance of nucleation and growth kinetics to the first order complex systems transition; and 4) utilize microemulsion techniques to examine effects of confinement on folding kinetics and to explore single molecule observation strategies.

9602884 C.奥斯汀·安吉尔“散装和介观液体的转变”该奖项将为亚利桑那州立大学物理系C.Austen Angell教授对澳大利亚悉尼大学六个月的访问中的三个月提供部分支持。安吉尔教授将与P.Harrowell教授和G.Warr教授合作研究玻璃化转变的动力学和热力学的当前方面，以及这种多晶化与介观系统中主要结构转变的关系，如蛋白质和RNA折叠转变。Angell对玻璃转变现象学的兴趣将与Harrowell在动力学伊辛模型以及由此产生的液体脆性的微观起源方面的理论专业知识以及Warr在微乳液结构和稳定性方面的经验相结合，以提高目前对玻璃以及玻璃和生物聚合物中的多晶性的理解。研究人员将1)在恒定化学势下使用系统大小控制来观察系统大小效应，特别是在尺寸类似于现在似乎出现在玻璃化温度附近的微不均相的系统中；2)基于促进的自旋微不均相模型进行理论研究，以确定产生水合蛋白质系统模糊的、玻璃-液体转变特征的必要条件；3)进行蛋白质折叠动力学的多步量热学研究，以评估成核和生长动力学与一阶复杂系统转变的相关性；以及4)利用微乳液技术来研究限制对折叠动力学的影响，并探索单分子观察策略。