U.S.-Germany Cooperative Research: Analysis of Differential Effects on RNA and DNA by Macrocycles

美德合作研究：大环化合物对 RNA 和 DNA 的不同影响分析

• 批准号: 9603213
• 负责人: W. Wilson
• 金额: $ 1.74万
• 依托单位: Georgia State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-15 至 2000-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9603213&HistoricalAwards=false
• 关键词: U.S.; Germany; Cooperative; Research; Analysis

An exploratory initial project between the PI and Hans-J`rg Schneider of the University of the Saarland has found a group of cationic cyclophanes that cause an unexpected base-pair opening in RNA, but stabilize the duplex state of DNA. These highly selective differential results with RNA and DNA have potential in drug development, biotechnology, and in enhancing our understanding of the mechanism of selective recognition and conformational reorganization of RNA and DNA. In order to develop an understanding of this process at the molecular level, it is essential to expand the analysis by probing the compound and RNA dependence of the base-opening reactions. Training of young investigators will be significantly enhanced by the opportunity to conduct research with the German group.

PI和萨尔兰大学的Hans-J‘rg Schneider之间的一个探索性的初步项目发现了一组阳离子环番化合物，它们会导致RNA中意外的碱基对开放，但会稳定DNA的双链状态。这些与RNA和DNA的高选择性差异结果在药物开发、生物技术以及加强我们对RNA和DNA的选择性识别和构象重组机制的理解方面具有潜在的潜力。为了在分子水平上了解这一过程，有必要通过探索化合物和RNA对碱基开放反应的依赖来扩展分析。有机会与这家德国集团一起进行研究，将大大加强对年轻调查人员的培训。