U.S.-Germany Cooperative Research: Invigorating the Chemistry of Nitriles: An Exploration of Functionalized Grignard Reagents

0203145弗莱明该奖项支持弗雷泽弗莱明和一名来自迪克讷大学的学生与德国慕尼黑大学有机化学研究所的保罗诺切尔合作。 该项目将侧重于一个根本不同的方法，以功能化的格氏试剂与潜在的显着推进双功能试剂的知识。 三个新的酰胺含格氏试剂将被检查去质子化和甲硅烷基化是用来掩盖和揭露羰基原位。 合作项目为弗莱明和研究生提供了一个绝佳的机会，以追求新的想法，培养创造性的解决方案，重大问题，并学习新技能。 该项目还提供了一个与德国集团建立长期关系的机会，并有可能继续交换学生。 学生将能够体验迪克讷大学更小，更个性化的环境，然后在更大，研究密集型的慕尼黑大学进行研究，在那里他们还将获得国际经验和联系。

0203145FlemingThis award supports Fraser Fleming and a student from Duquesne University in a collaboration with Paul Knochel of the Institute for Organic Chemistry at the University of Munich, Germany. The project will focus on a fundamentally different approach to functionalized Grignard reagents with potential for significantly advancing knowledge of bifunctional reagents. Three new amide-containing Grignard reagents will be examined where deprotonatin and silylation is used to mask and unmask the carbonyl group in situ. The collaborative project provides an excellent opportunity for Fleming and the graduate student to pursue new ideas, cultivate creative solutions to significant problems, and learn new skills. The project also provides an opportunity to establish a long-term relationship with the German group with the possibility of continued exchange of students. The students will be able to experience the smaller, more personal environment of Duquesne University, and then perform research at the larger, research-intensive University of Munich, where they will also garner international experience and contacts.