U.S.-Germany Cooperative Research: Invigorating the Chemistry of Nitriles: An Exploration of Functionalized Grignard Reagents

0203145弗莱明该奖项支持弗雷泽·弗莱明和杜肯大学的一名学生与德国慕尼黑大学有机化学研究所的保罗·克诺切尔合作。该项目将侧重于一种完全不同的方法来功能化格氏试剂，具有显著推进双功能试剂知识的潜力。三种新的含酰胺的格氏试剂将被检查，其中去质子化和硅基化是用来掩盖和揭露羰基在原位。这个合作项目为弗莱明和研究生提供了一个极好的机会来追求新的想法，培养创造性的解决重大问题的方法，并学习新的技能。该项目还提供了与德国集团建立长期合作关系的机会，并有可能继续交换学生。学生们将能够体验杜肯大学更小、更个性化的环境，然后在更大、研究密集型的慕尼黑大学进行研究，在那里他们也将获得国际经验和联系。

0203145FlemingThis award supports Fraser Fleming and a student from Duquesne University in a collaboration with Paul Knochel of the Institute for Organic Chemistry at the University of Munich, Germany. The project will focus on a fundamentally different approach to functionalized Grignard reagents with potential for significantly advancing knowledge of bifunctional reagents. Three new amide-containing Grignard reagents will be examined where deprotonatin and silylation is used to mask and unmask the carbonyl group in situ. The collaborative project provides an excellent opportunity for Fleming and the graduate student to pursue new ideas, cultivate creative solutions to significant problems, and learn new skills. The project also provides an opportunity to establish a long-term relationship with the German group with the possibility of continued exchange of students. The students will be able to experience the smaller, more personal environment of Duquesne University, and then perform research at the larger, research-intensive University of Munich, where they will also garner international experience and contacts.